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[pSer21]GSK-3α monoclonal antibody (9B8)

 
ADI-905-759-100 100 µg 378.00 USD
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Product Specification

Alternative Name:Glycogen synthate kinase-3α
 
Clone:9B8
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Phosphopeptide conjugated to KLH.
 
UniProt ID:P49840
 
Species reactivity:Human, Mouse, Rat
Dog
 
Specificity:Recognizes GSK-3α phosphorylated at Ser21.
 
Crossreactivity:Does not cross-react with the homologous phosphorylation site in GSK-3β (pSer9).
 
Applications:ELISA, WB
 
Purity Detail:Thiophilic adsorption and size exclusion chromatography purified.
 
Formulation:Lyophilized from 1ml of 2x PBS containing 0.09% sodium azide, PEG, and sucrose.
 
Reconstitution:Reconstitute with 1ml water (15 minutes at room temperature).
 
Use/Stability:Reconstituted antibody is stable at -80°C up to 1 year, at 4°C up to 3 months.
 
Handling:Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:

Glycogen Synthase Kinase 3 (GSK3) exists in two isoforms, alpha and beta (GSK3α, and GSK3β). GSK3 is an active kinase that becomes phosphorylated by PKB/akt upon growth factor stimulation. Phosphorylation of GSK3α at serine 21 or GSK3β at serine 9, respectively, leads to inhibition of kinase activity of the GSK3.

 
905-759 WB
Western blot analysis of A431 cells untreated (co), EGF stimulated (EGF), or pervanadate treated (VH), with GSK3α (phospho-Ser21) mAb (9B8).
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905-759 WB

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