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[pTyr783]PLC γ1 polyclonal antibody

 
ADI-905-758-100 100 µg 250.00 USD
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Product Specification

Alternative Name:Phospholipase C, PLCγ
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to human PLC γ1 phosphorylated at Tyr783.
 
UniProt ID:P19174
 
Species reactivity:Mouse
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~149kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing BSA, 0.09% sodium azide, and 50% glycerol.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:PLCγ-1 (Phosphoinositide-specific phospholipase C) is a 135 kDa isoenzyme belonging to the PLC family of proteins that hydrolyzes phosphatidylinositol 4,5-biphosphate to produce the second messengers IP3 and diacylglycerol (DAG). PLCγ-1 is ubiquitously expressed and modified by phosphorylation at two key tyrosine residues, Tyr783 and Tyr771, in response to non-receptor and receptor tyrosine kinase stimulation. Tyr783 phosphorylation is required for PLCγ-1 activation, and regulates EGF-induced association of PLCγ-1 with Akt.
 
905-758 WB
Western blot analysis of PLCg-1 (pTyr783). Lane 1: MW, Lane 2: 3T3, Lane 3: 3T3 + PDGF.
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905-758 WB

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