BMP4, mAb (26H16)

Alternative Name:	bone morphogenetic protein

Purity Detail:	Protein A affinity purified.

Formulation:	Liquid. In PBS, pH 7.2, containing BSA, 0.09% sodium azide, and 50% glycerol.

Clone:	26H16

Isotype:	Mouse IgG1

Immunogen:	Recombinant full length human BMP4.

Specificity:	Recognizes human BMP4. Detects bands of ~54kDa, ~42kDa and ~23kDa by Western blot.

Application:	Western Blot (1µg/ml, ECL) Optimal conditions must be determined individually for each application.

Long Term Storage:	-20°C

Miscellaneous/General:	Bone morphogenic protein 4 (BMP4) is a member of the TGF-beta superfamily that plays a critical role in mammalian mesenchymal development, influencing hematopoeisis and osteoblast differentiation and function. BMP-4 is secreted as 54 kDa inactive precursor peptides that dimerize and are activated following cleavage by members of the proprotein convertase family. Active BMP-4 binds type I and type II serine/threonine kinase receptors which signal via phosphorylation of Smad family proteins. BMP-4 and the highly homologous BMP-2 are functional orthologues of the decapentaplegic (dpp) gene in Drosophila that regulates embryonic leg and wing imaginal disc patterning and larval gut development.