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[pTyr1173]EGF receptor polyclonal antibody

ADI-905-753-100 100 µg 296.00 USD
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Product Specification

Alternative Name:EGFR, Epidermal growth factor receptor
Immunogen:Synthetic peptide corresponding to a portion of human EGF receptor phosphorylated at Tyr1173.
UniProt ID:P00533
Species reactivity:Human, Rat
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~170kDa by Western blot.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
Handling:Avoid freeze/thaw cycles.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:The epidermal growth factor receptor (EGFR) is a 170-kDa membrane bound receptor consisting of an extracellular ligand-binding domain, a single hydrophobic transmembrane region, and a tyrosine kinase domain-containing cytoplasmic region. Ligand binding induces receptor homo- or heterodimerization, triggering autophosphorylation of cytoplasmic tyrosine residues that provide docking sites for Src homology 2 (SH2) domain-containing signaling molecules. Src-mediated phosphorylation of EGFR at Tyr845 may contribute to EGFR hyperactivity in cancer, while autophosphorylation of EGFR at Tyr1068 and/or Tyr1173 in response to ligand binding is known to recruit cofactors (e.g. SHP1, RasGAP, SOS1, Grb2) that activate pathways associated with cell growth, apoptosis, adhesion, receptor endocytosis, and protein degradation.
905-753 WB
Western blot analysis of EGFR (pTyr1173) using A431 cell extracts treated with EGF. Lane 1: Molecular Weight Markers, Lane 2: A431, Lane 3: A431 + EGF.
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905-753 WB

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