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Adrenergic receptor α2a polyclonal antibody

 
ADI-905-748-100 100 µg 260.00 USD
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Product Specification

Alternative Name:ADRA2A, AR α-2a
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of mouse adrenergic receptor α2a.
 
UniProt ID:Q01338
 
Species reactivity:Human, Mouse, Rat
 
Crossreactivity:Predicted species reactivity based on epitope sequence homology: chimpanzee, rhesus macaque, dog, wild boar, bovine, cat, treeshrew, rabbit, platypus.
 
Applications:ELISA, IHC, WB
 
Application Notes:Suitable for cell-based and membrane-based ELISA.
Predicted MW of ~49kDa. Higher MW species (~ 75kDa) also observed by Western blot which may reflect post-translational modification or dimerization of the receptor.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
 
Handling:Keep on ice at all times.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Adrenergic receptors mediate the hormone and neurotransmitter functions of adrenaline and noradrenaline. Adrenoreceptors function in peripheral tissues and the central nervous system to regulate numerous vascular, metabolic, and neurological functions, and are the target for many therapeutically relevant drugs including those for the treatment of hypertension, asthma, benign prostatic hypertrophy, and depression. Adrenoreceptors are classified by three types and multiple subclasses (alpha1A,1B,1D; alpha2A,2B,2C; and beta1,2,3) based on pharmacological and molecular characteristics.
 
Manufacturer:Manufactured by Proteimax.
 
905-748 WB
Western blot analysis: MW marker (1) and 10µg rat brain extract (2) probed with Adrenergic Receptor (α2a) pAb at 3.0µg/ml.
905-748 c ELISA
Cellular ELISA: SKNSH cells endogenously expressing Adrenergic Receptor 2a were treated with indicated concentrations of agonist (Clondin) and antagonist (Yohimbine) and probed with Adrenergic Receptor (α2a) pAb (1:1000 of a stock solution of 1µg/μl) by ELISA. Data from vehicle treated cells were taken as 100%. Results are the mean ± SEM (n=3).
905-748 m ELISA
Membrane ELISA: Lewis rat striatum membranes (5µg/well) were treated with 1 μM concentrations of agonist (UK14304) and probed with Adrenergic Receptor (α2a) pAb (1:10 to 1:150 of a 0.1µg/μl stock solution) by ELISA. Data from vehicle treated cells were taken as 100%. Results are the mean ± SEM (n=6).
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905-748 WB 905-748 c ELISA 905-748 m ELISA

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