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Adrenergic receptor β2 polyclonal antibody

 
ADI-905-742-100 100 µg 313.00 USD
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Product Specification

Alternative Name:ADRB2, AR β-2
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the N-terminus of mouse adrenergic receptor β2.
 
UniProt ID:P18762
 
Species reactivity:Human, Mouse, Rat
 
Crossreactivity:Predicted species reactivity based on epitope sequence homology: chimpanzee, orangutan, tamarin monkey, gorilla, rhesus macaque, horse, hamster, guinea pig, wild boar, cat.
 
Applications:ELISA, IHC, WB
 
Application Notes:Suitable for cell-based and membrane-based ELISA.
Predicted MW of ~47kDa. Higher MW species (~65kDa) and intermediates also observed by Western blot which reflect post-translational modification of the receptor.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
 
Handling:Keep on ice at all times.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Adrenergic receptors mediate the hormone and neurotransmitter functions of adrenaline and noradrenaline. Adrenoreceptors function in peripheral tissues and the central nervous system to regulate numerous vascular, metabolic, and neurological functions, and are the target for many therapeutically relevant drugs including those for the treatment of hypertension, asthma, benign prostatic hypertrophy, and depression. Adrenoreceptors are classified by three types and multiple subclasses (alpha1A,1B,1D; alpha2A,2B,2C; and beta1,2,3) based on pharmacological and molecular characteristics.
 
Manufacturer:Manufactured by Proteimax.
 
905-742 WB
Western blot analysis: MW marker (1) and 20µg rat heart membrane extract (2) probed with Adrenergic Receptor (β2) pAb at 2.5µg/ml.
905-742 IHC
Immunohistochemistry analysis: Fluorescent confocal photomicrograph from rat brainstem. Neurons are labeled with Adrenergic Receptor (β2) pAb and Cy3 conjugated rabbit IgG antibody (H+L).
905-742 c ELISA
Cellular ELISA: HEK293 cells expressing Adrenergic Receptor β2 were treated with indicated concentrations of agonist (Isoproterenol) and antagonist (CPG12177) and probed with Adrenergic Receptor (β2) pAb (1:1000 of a stock solution of 1µg/μL ) by ELISA. Data from vehicle treated cells were taken as 100%. Results are the mean ± SEM (n=3).
905-742 m ELISA
Membrane ELISA: Lewis rat brain membranes (5µg/well) were treated with indicated concentrations of agonist (Isoproterenol) and antagonist (CGP12177) and probed with Adrenergic Receptor (β2) pAb (1:1000 of a stock solution of 1µg/μL) by ELISA. Data from vehicle treated cells were taken as 100%. Results are the mean ± SEM (n=3).
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905-742 WB 905-742 IHC 905-742 c ELISA 905-742 m ELISA

Product Literature References

Conformation state-sensitive antibodies to G-protein-coupled receptors: A. Gupta, et al.; J. Biol. Chem. 282, 5116 (2007), Application(s): ELISA, Abstract; Full Text

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