Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Dopamine receptor D2 polyclonal antibody

ADI-905-740-100 100 µg 329.00 USD
Do you need bulk/larger quantities?

Product Specification

Alternative Name:DRD, D2R
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of mouse dopamine receptor D2
UniProt ID:P61168
Species reactivity:Human, Mouse, Rat
Crossreactivity:Predicted species reactivity based on epitope sequence homology: rhesus macaque, chimpanzee, horse, arctic fox, dog, opossum, ferret.
Applications:ELISA, IHC, WB
Application Notes:Suitable for cell-based and membrane-based ELISA.
Predicted MW of ~51kDa.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.
Handling:Keep on ice at all times.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:Dopamine is the predominant catecholamine neurotransmitter in the mammalian brain, where it regulates locomotor, emotional, memory, and dietary intake functions, as well as peripheral roles such as hormone secretion and renal function. Dopamine receptors (D1-D5) are members of the seven transmembrane domain containing GPCR family, and are the target of several anti-psychosis and anti-Parkinsonian drugs. The D2, D3, and D4 receptors signal via coupling of Gi/Go alpha G-protein subunits to inhibit adenylyl cyclase activity and modulate cellular potassium and calcium ion channel conductance. Expression of the D2 receptor is found primarily in the brain (striatum, olfactory tubercle, and nucleus accumbens) and in the anterior and intermediate lobes of the pituitary.
Manufacturer:Manufactured by Proteimax.
905-740 WB
Western blot analysis: MW marker (1) and 10µg of rat heart membrane extract (2) probed with Dopamine Receptor (D2) pAb at 4.0µg/ml.
905-740 IHC
Immunohistochemistry analysis: Fluorescent confocal photomicrograph of rat cerebral cortex. Neurons are labeled with Dopamine Receptor (D2) pAb in conjunction with Cy3 conjugated rabbit IgG antibody (H+L).
905-740 c ELISA
Cellular ELISA: HEK293 cells expressing dopamine receptor (D2) were treated with indicated concentrations of agonist (Quinpirol) and antagonist (Siperone) and probed with Dopamine Receptor (D2) pAb (1:1000 of a stock solution of 1μg/μL) by cellular ELISA. Data from vehicle treated cells were taken as 100%. Results are the mean ±SEM (n=3).
Please mouse over
905-740 WB 905-740 IHC 905-740 c ELISA

Product Literature References

Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states: A.S. Heimann, et al.; PloS One 12, e0187306 (2017), Abstract; Full Text

Related Products

Goat anti-rabbit IgG, polyclonal antibody (HRP conjugate) 

ELISA, IHC, WB | Print as PDF
ADI-SAB-300-J 1 ml 124.00 USD
Do you need bulk/larger quantities?

Related Literature

Essential Research Tools for Neurodegeneration & Neural Signaling
Essential Research Tools for Neurodegeneration & Neural Signaling
Download as PDF

All new literature pieces

Recommend this page

For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2019 Enzo Life Sciences, Inc.,