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XBP-1 polyclonal antibody

 
ADI-905-739-100 100 µg 356.00 USD
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Product Specification

Alternative Name:X-box binding protein 1
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human XBP-1.
 
UniProt ID:P17861
 
Species reactivity:Human, Mouse
 
Applications:ICC, IHC, WB
 
Recommended Dilutions/Conditions:Western Blot (1-2µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~43kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of misfolded proteins in the endoplasmic reticulum (ER). XBP-1 mRNA is spliced by IRE1p under ER stress, resulting in a 371 amino acid protein (XBP- 1s) which is translocated to the nucleus where it binds to the regulatory elements of downstream genes. XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones grp78 and grp94.
 
905-739 WB
Western blot analysis of XBP-1 in HepG2 cell lysate with XBP-1 antibody at (A) 0.5, (B) 1 and (C) 2µg/ml.
905-739 ICC
Immunocytochemistry analysis of XBP-1 in HepG2 cells with XBP-1 antibody at 10µg/ml.
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905-739 WB 905-739 ICC

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