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DRAM polyclonal antibody

 
ADI-905-738-100 100 µg 366.00 USD
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Product Specification

Alternative Name:Damage-regulated autophagy modulator
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human DRAM.
 
UniProt ID:Q8N682
 
Species reactivity:Human, Mouse, Rat
 
Applications:IHC, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (2.5µg/ml)
Western Blot (0.5-1.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~31kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA and Bax, and that the signaling pathways regulated by these genes together promote a full cell death response.
 
905-738 WB
Western blot analysis of DRAM in K562 cell lysate with DRAM antibody at (A) 0.5, (B) 1 and (C) 2µg/ml.
905-738 IHC
Immunohistochemistry analysis of DRAM in human liver tissue with DRAM antibody at 2.5µg/ml.
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905-738 WB 905-738 IHC

Product Literature References

DRAM1 regulates autophagy flux through lysosomes: X.D. Zhang, et al.; PLoS One 8, e63245 (2013), Application(s): WB using A549 cells, Abstract; Full Text
Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-κB/p53 signaling pathway: D.R. Cui, et al.; Neuroscience 246, 117 (2013), Application(s): WB using rat tissue homogenates, Abstract;
p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms: Y. Wang, et al.; Eur. J. Neurosci. 30, 2258 (2009), Abstract;

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