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PEN2 polyclonal antibody

 
ADI-905-736-100 100 µg 357.00 USD
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Product Specification

Alternative Name:γ-secretase subunit PEN-2, Presenilin enhancer protein 2
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human PEN2.
 
UniProt ID:Q9NZ42
 
Species reactivity:Human, Mouse, Rat
 
Applications:IHC, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (10µg/ml)
Western Blot (0.5-1.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:PEN2, in addition to nicastrin, presenilin, and APH-1, forms the gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is thought to be required for the generation of neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimers disease. Gamma- secretase will cleave the amyloid precursor protein (APP) within the intramembrane region, resulting in either the nontoxic p3 (from the alpha and gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and gamma cleavage site).
 
905-736 WB
Western blot analysis of PEN2 in A-20 cell lysate with PEN2 antibody at (A) 0.5 and (B) 1µg/ml.
905-736 IHC
Immunohistochemistry analysis of PEN2 in rat lung tissue with PEN2 antibody at 2.5µg/ml.
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905-736 WB 905-736 IHC

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