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BMI-1 polyclonal antibody

 
ADI-905-731-100 100 µg 347.00 USD
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Product Specification

Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the middle of human BMI-1.
 
UniProt ID:P35226
 
Species reactivity:Human, Mouse, Rat
 
Applications:ICC, WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (10µg/ml)
Western Blot (0.5-1.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~33kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:The transcriptional repressor BMI-1 was first identified as a proto-oncogene that cooperates with c-myc in the generation of lymphomas in murine models. BMI-1 belongs to the Polycomb-group (PcG) family of proteins involved in axial patterning, hematopoeisis, cell growth, and senescence. A major target of BMI-1 is the INK4A/ARF locus which encodes tumor suppressor proteins p16 and p19ARF. Studies have also shown that BMI-1 is overexpressed in numerous human cancers, including lymphomas, breast, colorectal, and prostate cancers.
 
905-731 WB
Western blot analysis of BMI-1 in K562 cell lysate with BMI-1 antibody at (A) 0.5, (B) 1 and (C) 2µg/ml.
905-731 ICC
Immunocytochemistry analysis of BMI-1 in K562 cells with BMI-1 antibody at 10µg/ml.
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905-731 WB 905-731 ICC

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BMI-1 Polyclonal antibody
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