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ATF6 polyclonal antibody

 
ADI-905-729-100 100 µg 366.00 USD
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Product Specification

Alternative Name:Activating transcription factor 6
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human ATF6.
 
UniProt ID:P18850
 
Species reactivity:Human, Mouse
 
Applications:ICC, WB
 
Recommended Dilutions/Conditions:Immunocytochemistry (10µg/ml)
Western Blot (0.5-1.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~88kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Disruptions of protein folding and maturation in the endoplasmic reticulum (ER) result in the activation of the unfolded protein response (UPR), an integrated cellular signaling pathway that transmits information from the ER lumen to the cytoplasm and nucleus. Activating transcription factor 6 (ATF6) as well as the ER-transmembrane protein kinases IRE1p and PERK are the major transducers of the UPR. ATF6 is an ER transmembrane protein that is normally bound to the ER chaperone Grp78, but upon ER stress is released from Grp78 and proteolytically cleaved to yield a cytosolic fragment which then migrates to the nucleus. Nuclear ATF6, together with the transcription factor XBP-1, activates transcription of UPR-responsive genes.
 
905-729 WB
Western blot analysis of ATF6 in MDA-MB-361 cell lysate with ATF6 antibody at (A) 0.5 and (B) 1µg/ml.
905-729 ICC
Immunocytochemistry analysis of ATF6 in A20 with ATF6 antibody at 10µg/ml.
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905-729 WB 905-729 ICC

Product Literature References

Resveratrol triggers ER stress-mediated apoptosis by disrupting N-linked glycosylation of proteins in ovarian cancer cells: H. Gwak, et al. ; Cancer Lett. 371, 347 (2016), Application(s): Activation of ER stress sensors triggers cellular adaptation, Abstract;

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