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[pTyr1068]EGF receptor polyclonal antibody

 
ADI-905-707-100 100 µg 269.00 USD
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Product Specification

Alternative Name:EGFR, epidermal growth factor receptor
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to human EGFR phosphorylated at Tyr1068.
 
UniProt ID:P00533
 
Species reactivity:Human, Rat
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~170kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The epidermal growth factor receptor (EGFR) is a 170-kDa membrane bound receptor consisting of an extracellular ligand-binding domain, a single hydrophobic transmembrane region, and a tyrosine kinase domain-containing cytoplasmic region. Ligand binding induces receptor homo- or heterodimerization, triggering autophosphorylation of cytoplasmic tyrosine residues that provide docking sites for Src homology 2 (SH2) domain-containing signaling molecules. Src-mediated phosphorylation of EGFR at Tyr845 may contribute to EGFR hyperactivity in cancer, while autophosphorylation of EGFR at Tyr1068 and/or Tyr1173 in response to ligand binding is known to recruit cofactors (e.g. SHP1, RasGAP, SOS1, Grb2) that activate pathways associated with cell growth, apoptosis, adhesion, receptor endocytosis, and protein degradation.
 
905-707 WB
Western blot analysis of EGFR (pTyr1068) using A431 cell extracts treated with EGF. Lane 1: Molecular Weight Markers, Lane 2: A431, Lane 3: A431 + EGF.
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905-707 WB

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