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[pTyr1068]EGF receptor polyclonal antibody

 
ADI-905-707-100 100 µg 282.00 USD
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Product Specification

Alternative Name:EGFR, epidermal growth factor receptor
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to human EGFR phosphorylated at Tyr1068.
 
UniProt ID:P00533
 
Source:Purified from rabbit serum.
 
Species reactivity:Human, Rat
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~170kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The epidermal growth factor receptor (EGFR) is a 170-kDa membrane bound receptor consisting of an extracellular ligand-binding domain, a single hydrophobic transmembrane region, and a tyrosine kinase domain-containing cytoplasmic region. Ligand binding induces receptor homo- or heterodimerization, triggering autophosphorylation of cytoplasmic tyrosine residues that provide docking sites for Src homology 2 (SH2) domain-containing signaling molecules. Src-mediated phosphorylation of EGFR at Tyr845 may contribute to EGFR hyperactivity in cancer, while autophosphorylation of EGFR at Tyr1068 and/or Tyr1173 in response to ligand binding is known to recruit cofactors (e.g. SHP1, RasGAP, SOS1, Grb2) that activate pathways associated with cell growth, apoptosis, adhesion, receptor endocytosis, and protein degradation.
 
[pTyr1068]EGF receptor polyclonal antibody Western blot
Western blot analysis of EGFR (pTyr1068) using A431 cell extracts treated with EGF. Lane 1: Molecular Weight Markers, Lane 2: A431, Lane 3: A431 + EGF.
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[pTyr1068]EGF receptor polyclonal antibody Western blot

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