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AIB1 monoclonal antibody (50B6)

 
ADI-905-706-100 100 µg 269.00 USD
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Product Specification

Alternative Name:Nuclear receptor coactivator 3, NCoA-3, SRC-3
 
Clone:50B6
 
Host:Mouse
 
Immunogen:Recombinant human AIB1.
 
UniProt ID:Q9Y6Q9
 
Species reactivity:Human
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~160kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:AIB1 is a member of the p160/steroid receptor coactivator (SRC) family, named for its common amplification in breast cancer. Members of this family include a defined nuclear receptor box motif (LxxLL) that is critical for binding to nuclear hormone receptors, and two C-terminal activation domains that bind secondary coactivators such as the p300/CREB binding protein (CBP) and CARM-1 to confer acetyltransferase or methyltransferase downstream signals, respectively. AIB1 binds to estrogen receptor (ER), and its overexpression in hormone-responsive cancers and frequent amplification in breast and other cancers make it a focus for the treatment of cancer and the study of hormone receptor signaling.
 
905-706 WB
Western blot analysis of AIB1 using MCF-7 and T-47D cell extracts. Lane 1: Molecular Weight Markers, Lane 2: MCF-7, Lane 3: T-47D.
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905-706 WB

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