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Pax3 monoclonal antibody (C2)

 
ADI-905-688-100 100 µg 301.00 USD
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Product Specification

Clone:C2
 
Host:Mouse
 
Isotype:IgG2a
 
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of quail Pax3.
 
UniProt ID:P23760
 
Species reactivity:Human
 
Applications:IHC (PS), WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~53kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Pax3 is a member of the paired box family of nuclear transcription factors that function in the transcriptional control of pattern development during embryogenesis. Pax3 is characterized by a conserved N-terminal paired box DNA binding domain, and a C-terminal transcriptional activation domain. In humans, loss of function mutations in Pax3 are associated with type I and type III Waardenburg Syndrome, characterized by varying degrees of developmental abnormalities in facial structure, pigmentation, limb development, and hearing. Translocation t(2;13) of the Pax3 loci to the fork head (FKHR) transcription factor gene results in the creation of a Pax3-FKHR fusion gene with transcriptional hyperactivity manifested in alveolar rhabdomyosarcoma.
 
905-688 WB
Western blot analysis of 624 Mel nuclear lysates probed with Pax-3 mAb (C2) at 1µg/ml
ADI-905-688 IHC1
IHC Analysis: Human skeletal muscle tissue stained with Pax3, mAb (C2) at 10µg/ml.
ADI-905-688 IHC2
IHC Analysis: Human skin tissue stained with Pax3, mAb (C2) at 10µg/ml.
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905-688 WB ADI-905-688 IHC1 ADI-905-688 IHC2

Product Literature References

Loading of PAX3 to Mitotic Chromosomes Is Mediated by Arginine Methylation and Associated with Waardenburg Syndrome: T.F. Wu, et al.; J. Biol. Chem. 290, 20556 (2015), Abstract; Full Text

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