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Smac/DIABLO monoclonal antibody (79-1-83)

 
ADI-905-684-100 100 µg 248.00 USD
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Product Specification

Alternative Name:Second mitochondria-derived activator of caspase
 
Clone:79-1-83
 
Host:Mouse
 
Isotype:IgG2b
 
Immunogen:Recombinant full length human Smac/DIABLO.
 
UniProt ID:Q9NR28
 
Species reactivity:Human
Monkey
 
Applications:IHC (PS), WB
 
Recommended Dilutions/Conditions:Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Smac/DIABLO is one of the pro-apoptotic proteins normally found in the intermembrane space of the mitochondria. In response to apoptotic stimuli, Smac/DIABLO is released into the cytosol resulting in permeabilization of the mitochondrial membrane. Cytosolic Smac/DIABLO activates caspase-9 by binding IAP proteins. Changes in the expression level of Smac/DIABLO have been demonstrated in a number of human cancers including melanoma, ovary, and prostate.
 
905-684 WB
Western blot analysis of Smac/Diablo. Lane 1: MW marker, Lane 2: 293, Lane 3: HeLa, Lane 4: Jurkat, Lane 5: Vero.
ADI-905-684 IHC1
IHC Analysis: Human adrenal tissue stained with Smac/DIABLO, mAb (79-1-83) at 10µg/ml.
ADI-905-684 IHC2
IHC Analysis: Human testis tissue stained with Smac/DIABLO, mAb (79-1-83) at 10µg/ml.
ADI-905-684 IHC3
IHC Analysis: Human tonsil tissue stained with Smac/DIABLO, mAb (79-1-83) at 10µg/ml.
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905-684 WB ADI-905-684 IHC1 ADI-905-684 IHC2 ADI-905-684 IHC3

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