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Insulin receptor β monoclonal antibody (C18C4)

 
ADI-905-683-100 100 µg 291.00 USD
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Product Specification

Alternative Name:INSR
 
Clone:C18C4
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Recombinant cytoplasmic domain of human Insulin Receptor β.
 
UniProt ID:P06213
 
Species reactivity:Human, Mouse, Rat
Bovine, Hamster, Porcine, Rabbit, Sheep
 
Applications:WB
 
Recommended Dilutions/Conditions:Western Blot (1:1,000, colorimetric, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~98kDa by Western blot.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.
 
ADI-905-683 WB
Western blot analysis of ADI-905-683: Lane 1: MW Marker, Lane 2: HeLa lysate, Lane 3: MCF-7 lysate, Lane 4: PC-12 lysate, Lane 5: 3T3 lysate.
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ADI-905-683 WB

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