| ADI-905-683-100 | 100 µg | 373.00 USD |  |
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| Alternative Name: | INSR |
| Clone: | C18C4 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Recombinant cytoplasmic domain of human Insulin Receptor β. |
| UniProt ID: | P06213 |
| Source: | Purified from ascites. |
| Species reactivity: | Human, Mouse, Rat Bovine, Hamster, Porcine, Rabbit, Sheep |
| Applications: | WB |
| Recommended Dilutions/Conditions: | Western Blot (1:1,000, colorimetric, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~98kDa by Western blot. |
| Purity Detail: | Protein G affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.2, containing 0.09% sodium azide and 50% glycerol. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes. |
| Regulatory Status: | RUO - Research Use Only |
