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[pTyr1150/Tyr1151]Insulin receptor monoclonal antibody (10C3)

 
ADI-905-645-100 100 µg 399.00 USD
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Product Specification

Alternative Name:INSR
 
Clone:10C3
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Synthetic peptide corresponding to a portion of human Insulin Receptor phosphorylated at Tyr1150/1151, conjugated to KLH.
 
UniProt ID:P06213
 
Species reactivity:Human
 
Crossreactivity:Cross-reacts with IGF1 receptor.
 
Applications:ELISA, WB
 
Recommended Dilutions/Conditions:ELISA (0.1µg/ml)
Western Blot (0.2-0.5µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Thiophilic adsorption and size exclusion chromatography purified.
 
Formulation:Liquid. In PBS containing 50% glycerol, PEG, sucrose, and 0.09% sodium azide.
 
Use/Stability:Stable at -20°C up to 1 year.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.
 
905-645 WB
Western blot analysis of untreated (1) or insulin-stimulated (2) MCA-MB-213 cancer cells probed with Insulin Receptor (pTyr1150/1151) mAb (10C3).
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905-645 WB

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