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[pTyr1316]IGF-1 receptor monoclonal antibody (2B9)

 
ADI-905-643-100 100 µg 420.00 USD
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Product Specification

Alternative Name:Insulin-like growth factor-1 receptor, IGF-1R
 
Clone:2B9
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Synthetic peptide corresponding to a portion of human IGF-1 receptor phosphorylated at Tyr1316.
 
UniProt ID:P08069
 
Species reactivity:Human
 
Applications:ELISA, WB
 
Recommended Dilutions/Conditions:ELISA (0.1µg/ml)
Western Blot (1µg/ml, ECL)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~97kDa by Western blot.
 
Purity Detail:Thiophilic adsorption and size exclusion chromatography purified.
 
Formulation:Lyophilized from 1ml of 2x PBS containing 0.09% sodium azide, PEG, and sucrose.
 
Reconstitution:Reconstitute with 1ml water (15 minutes at room temperature).
 
Use/Stability:Stable at -80°C up to 1 year, at 4°C up to 3 months.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Insulin-like growth factor-I (IGF-I) is a polypeptide hormone similar in structure to insulin. It is involved in regulation of neuronal growth and development in the central and peripheral nervous system. IGF-1 is a potent inhibitor of apoptosis in neurons, and activates the Akt signaling pathway via the IGF-1R and Insulin receptors. The IGF-1R acts as a receptor for IGF-1 and the related IGF-2, and is subject to autophosphorylation on multiple tyrosine residues that regulate receptor activation and assembly of signal transduction complexes.
 
905-643 WB
Western blot analysis of untreated (1), Insulin-treated (2), or IGF1-treated (3) HeLa cell lysates, probed with IGF1 Receptor (pTyr1316) mAb (2B9).
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905-643 WB

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