Endothelin receptor ET_B, mAb (8Z11)

Alternative Name:	EDNRB, ETB

Purity Detail:	Protein A affinity purified.

Formulation:	Lyophilized. In PBS containing 1% BSA and 0.05% sodium azide.

Clone:	8Z11

Immunogen:	Recombinant human 6hN-ETBR with ET-1 bound.

Source/Host:	From mouse.

Specificity:	Recognizes human endothelin receptor ET_B.

Application:	Immunohistochemistry (5µg/ml) Immunoprecipitation (2-5µg/ml) Western Blot (2-5µg/ml) Optimal conditions must be determined individually for each application.

Long Term Storage:	-20°C

Miscellaneous/General:	Two kinds of receptors for Endothelin have been found, namely Endothelin-A (ET-A) receptor and Endothelin-B (ET-B) receptor. ET-A receptor is ET-1 specific and expressed in lung, aorta, atrium, liver, muscle, cerebral cortex, cerebellum, kidney, adrenal, duodenum, colon and placenta at the mRNA or cDNA level. ET-B receptor lacks isopeptide specificity and is found in liver, lung, placenta, kidney, heart and brain. Cellular localization of ET receptors in these organs or tissues has not been elucidated. Stromal cells, but not epithelial cells of the breast, express ET-1 receptor in vitro.