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Cytochrome c monoclonal antibody (6H2.B4)

 
ADI-905-634-100 100 µg 258.00 USD
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Replaces Prod. #: ALX-804-295

Product Specification

Alternative Name:Cyt c
 
Clone:6H2.B4
 
Host:Mouse
 
Isotype:IgG1
 
Immunogen:Native rat Cytochrome c.
 
UniProt ID:P62898
 
Species reactivity:Human, Mouse, Rat
 
Applications:ELISA, IP
 
Application Notes:Estimated molecular weight of ~13kDa.
 
Purity Detail:Protein G affinity purified.
 
Formulation:Liquid. In PBS containing 0.1% sodium azide. Concentration 1mg/ml.
 
Handling:Avoid freeze/thaw cycles.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Cytochrome c, which is a critical component of the electron transport chain, is a component of the functional apoptosome. Upon release from the mitochondria, cytochrome c binds to the adaptor proteins Apaf-1 and procaspase-9 to form a cytosolic apoptosome complex. This event results in activation of procaspase-9 and its subsequent cleavage and activation of caspase-3 leading to the degradation of a series of cellular substrates and subsequently cell death.
 

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