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TNF receptor 2 polyclonal antibody

 
ADI-905-593-1 1 ml 366.00 USD
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Product Specification

Alternative Name:Tumor necrosis factor receptor 2, TNF-R2
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of mouse TNF receptor 2.
 
UniProt ID:P25119
 
Species reactivity:Human, Mouse, Rat
 
Applications:IHC
 
Recommended Dilutions/Conditions:Immunohistochemistry (1:50)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~75kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS, pH 7.6, containing 1% BSA and 0.1% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Tumor necrosis factor alpha (TNF alpha), also known as cachectin, is a 17.5 kDa 157 amino acid member of the TNF superfamily of cytokines that is a potent lymphoid factor with effects on a wide range of target cells. Active TNFalpha is produced in both soluble and membrane-anchored trimers by macrophages, NK cells, and T- and B-lymphocytes. TNF exerts proinflammatory signals via binding and inducing trimerization of TNF-receptor1 (TNF-R1) expressed on most normal and transformed cells, or to TNF-receptor 2 (TNF-R2), expressed on endothelial and most immune cells. TNF signaling regulates hematopeiesis, differentation, endothelial cell activation, apoptosis, lipid metabolism, tumor progression, and immune suveillance, and dysregulation of TNF or its receptors is implicated in numerous disease states including cancer, osteoporosis, autoimmune disease, diabetes, and atherosclerosis.
 
ADI-905-593 IHC
Immunohistochemistry analysis of human liver carcinoma stained with TNF receptor 2, pAb.
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ADI-905-593 IHC

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