Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Stat5α polyclonal antibody

 
ADI-905-556-1 1 ml 310.00 USD
Do you need bulk/larger quantities?
 

Product Specification

Alternative Name:Signal transducer and activator of transcription 5α
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human Stat5α.
 
UniProt ID:P42229
 
Gene/Protein Identifier:6776 (Entrez GeneID)
 
Species reactivity:Human, Mouse, Rat
 
Applications:IHC, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (1:200)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~95kDa by Western blot.
 
Purity Detail:Affinity purified.
 
Formulation:Liquid. In PBS, pH 7.6, containing 1% BSA and 0.1% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:The signal transducer and activator of transcription (STAT) proteins serve as both cytoplasmic signaling and nuclear transcription activating proteins. STAT family proteins are comprised of an N -terminal domain that facilitates binding of cofactors, central DNA binding and SH2 domains, and a C -terminal transactivation domain. In response to a specific cytokine signal, STAT proteins are phosphorylated on conserved tyrosine residues. Phosphorylated STAT proteins dimerize via their SH2 domains and move to the nucleus. The STAT dimers bind to specific DNA elements resulting in transcriptional regulation of downstream target genes. STAT5 consists of two highly related genes encoding STAT5α and STAT5β proteins, which are 96% similar at the amino acid level. STAT5 is activated by phosphorylation at Tyr694 (STAT5α) or Tyr699 (STAT5β) in response to prolactin, growth hormone, thrombopoietin, erythropoietin, GM-CSF, IL-2, IL-3, IL-5, IL-7, IL-9, and IL-15 signals. Studies in knockout mice indicate STAT5α is the principal mediator of mammary gland development and lactogenesis.
 
905-556 IHC
Immunohistochemistry analysis of breast carcinoma stained with STAT5a pAb.
ADI-905-556 WB
Western Blot analysis of K562 cell lysate with Stat5α pAb.
Please mouse over
905-556 IHC ADI-905-556 WB

Related Products

Goat anti-rabbit IgG, polyclonal antibody (HRP conjugate) 

ELISA, IHC, WB | Print as PDF
 
ADI-SAB-300-J 1 ml 118.00 USD
Do you need bulk/larger quantities?
 

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
STAT
By biological activity:
STAT Polyclonal antibody
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,