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p53 polyclonal antibody

 
ADI-905-510-1 1 ml 248.00 USD
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Product Specification

Alternative Name:TRP53, Tumor protein p53
 
Host:Rabbit
 
Immunogen:Recombinant human full length wild-type p53.
 
UniProt ID:P04637
 
Gene/Protein Identifier:7157 (Entrez GeneID)
 
Species reactivity:Human
 
Applications:IHC
 
Recommended Dilutions/Conditions:Immunohistochemistry (1:50)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~53kDa by Western blot.
 
Purity Detail:Affinity purified.
 
Formulation:Liquid. In PBS, pH 7.4, containing BSA and sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to Mdm2, SV40 T antigen and human Papilloma virus E6 protein. p53 senses DNA damage and facilitates its repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovary, bladder, colon, lung, and melanoma.
 
905-510 IHC
Immunohistochemistry analysis of colon carcinoma stained with p53 pAb.
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905-510 IHC

Product Literature References

P53 mediates estradiol induced activation of apoptosis and DNA repair in non-malignant colonocytes: C.C. Weige, et al.; J. Steroid Biochem. Mol. Biol. 128, 113 (2012), Application(s): WB using mouse cell lysates, Abstract;

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