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Osteopontin polyclonal antibody

 
ADI-905-500-1 1 ml 333.00 USD
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Product Specification

Alternative Name:OPN, SPP1, Secreted phosphoprotein 1, Bone sialoprotein 1
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the internal domain of human OPN (osteopontin).
 
UniProt ID:P10451
 
Gene/Protein Identifier:6696 (Entrez GeneID)
 
Species reactivity:Human
 
Applications:IHC (PS)
 
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 1:100)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~34kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS, pH 7.4, containing BSA and sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to be a positive indicator of colon and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.
 
905-500 IHC
Immunohistochemistry analysis of human breast cancer cells stained with Osteopontin, pAb.
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905-500 IHC

Product Literature References

The diameter of nanotubes formed on Ti-6Al-4V alloy controls the adhesion and differentiation of Saos-2 cells: E. Filova, et al. ; Int. J. Nanomedicine 10, 7145 (2015), Application(s): Immunofluorescence staining, osteogenic differentiation, Abstract; Full Text

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