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iNOS polyclonal antibody

 
ADI-905-431-1 1 ml 345.00 USD
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Product Specification

Alternative Name:NOS2, NOS II, Nitric oxide synthase (inducible), Hepatocyte NOS
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of mouse iNOS.
 
UniProt ID:P29477
 
Gene/Protein Identifier:NM_010927 (RefSeq)
 
Species reactivity:Human, Mouse, Rat
 
Applications:IHC (PS)
 
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 1:100)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~130kDa by Western blot.
 
Purity Detail:Affinity purified.
 
Formulation:Liquid. In 10mM PBS, pH 7.6, containing 1% BSA and 0.1%sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Nitric oxide (NO) is synthesized from L-arginine, oxygen, and NADPH by three known isoforms of heme-containing flavoproteins termed NO synthases (NOS I-III). Analysis of cDNA clones has identified three distinct NOS genes in mammals: neuronal (nNOS/NOS-I), endothelial (eNOS/NOS-III), and inducible (iNOS/NOS-II). eNOS and nNOS are constitutively expressed, agonist-triggered, Ca2+/calmodulin-dependent, and are inhibited by L-arginine analogues (L-NNA, L-NMMA). They are expressed in endothelium, adrenal glands, brain, and platelets. iNOS is inducible, Ca2+/calmodulin-independent, and also inhibited by NMMA and L-NNA. It is expressed in macrophages, hepatocytes, tumor cells, vascular smooth muscle and endothelial cells.
 
905-431 IHC
Immunohistochemistry analysis of human lung stained with iNOS pAb.
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905-431 IHC

Product Literature References

Carbenoxolone inhibits TRPV4 channel-initiated oxidative urothelial injury and ameliorates cyclophosphamide-induced bladder dysfunction: X. Zhang, et al.; J. Cell. Mol. Med. (2017), Abstract; Full Text
Iridoid glycosides from the flowers of Gentiana macrophylla Pall. ameliorate collagen-induced arthritis in rats: N. Jia, et al.; J. Ethnopharmacol. 189, 1 (2016), Application(s): Western blot, Abstract;
Metformin Ameliorates Dysfunctional Traits of Glibenclamide- and Glucose-Induced Insulin Secretion by Suppression of Imposed Overactivity of the Islet Nitric Oxide Synthase-NO System: I. Lundquist, et al.; PLoS One 11, e0165668 (2016), Abstract; Full Text
Arginase 1+ microglia reduce Aβ plaque deposition during IL-1β-dependent neuroinflammation: J.D. Cherry, et al.; J. Neuroinflammation 12, 203 (2015), Application(s): Immunohistochemistry with brain tissue, Abstract; Full Text
Regulatory Effects of Caffeic Acid Phenethyl Ester on Neuroinflammation in Microglial Cells: C.F. Tsai, et al.; Int. J. Mol. Sci. 16, 5572 (2015), Application(s): Western Blotting, Abstract; Full Text

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