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GluR 2/3 polyclonal antibody

 
ADI-905-414-1 1 ml 419.00 USD
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Product Specification

Alternative Name:Glutamate receptor 2/3
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human GluR2/3.
 
UniProt ID:P42262 (GluR2), P42263 (GluR3)
 
Species reactivity:Human, Mouse, Rat
Avian, Monkey
 
Applications:IHC
 
Recommended Dilutions/Conditions:Immunohistochemistry (1:50)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects bands of ~99kDa (GluR2) and ~101kDa (GluR3) by Western blot.
 
Purity Detail:Affinity purified.
 
Formulation:Liquid. In PBS, pH 7.4, containing BSA and sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Glutamate receptors constitute the principal excitatory neurotransmitter receptors in the brain. Two classes of Glutamate receptors exist: inotropic receptors and Metabotropic receptors. Inotropic glutamate receptors are oligomeric complexes which are ligandgated calcium channels. Metabotropic glutamate receptors, on the otherhand, are G-protein coupled receptors (GPCRs), which when activated can activate phospholipases or adenylylcyclase, depending on the neuron.
 
905-414 IHC
Immunohistochemistry analysis of human cerebellum stained with GluR2/3 pAb.
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905-414 IHC

Product Literature References

Role of Site-Specific N-Glycans Expressed on GluA2 in the Regulation of Cell Surface Expression of AMPA-Type Glutamate Receptors: Y. Takeuchi, et al.; PLoS One 10, e0135644 (2015), Application(s): Immunoflurescence staining, Abstract; Full Text

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