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eNOS polyclonal antibody

 
ADI-905-386-1 1 ml 334.00 USD
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Product Specification

Alternative Name:NOS3, cNOS, NOS III, Nitric oxide synthase (endothelial)
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human eNOS. The sequence is conserved in mouse, rat, bovine, dog and pig.
 
UniProt ID:P29474
 
Gene/Protein Identifier:4846 (Entrez GeneID)
 
Species reactivity:Human, Mouse, Rat
Bovine, Dog, Porcine
 
Applications:IHC
 
Recommended Dilutions/Conditions:Immunohistochemistry (1:70)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Purity Detail:Affinity purified.
 
Formulation:Liquid. In PBS, pH 7.4, containing BSA and sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Nitric oxide (NO) is synthesized from L-arginine, oxygen, and NADPH by three known isoforms of heme-containing flavoproteins termed NO synthases (NOS I-III). Analysis of cDNA clones has identified three distinct NOS genes in mammals: neuronal (nNOS/NOS-I), endothelial (eNOS/NOS-III), and inducible (iNOS/NOS-II). eNOS and nNOS are constitutively expressed, agonist-triggered, Ca2+/calmodulin-dependent, and are inhibited by L-arginine analogues (L-NNA, L-NMMA). They are expressed in endothelium, adrenal glands, brain, and platelets. iNOS is inducible, Ca2+/calmodulin-independent, and also inhibited by NMMA and L-NNA. It is expressed in macrophages, hepatocytes, tumor cells, vascular smooth muscle and endothelial cells.
 
905-386 IHC
immunohistochemistry analysis of human placenta stained with eNOS, pAb.
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905-386 IHC

Product Literature References

Markers of Islet Endothelial Dysfunction Occur in Male db/db Mice and May Contribute to Reduced Insulin Release: M.F. Hogan, et al.; Endocrinology 158, 293 (2017), Abstract;

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