| ADI-905-386-1 | 1 ml | 368.00 USD |  |
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| Alternative Name: | NOS3, cNOS, NOS III, Nitric oxide synthase (endothelial) |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to the sequence near the C-terminus of human eNOS. The sequence is conserved in mouse, rat, bovine, dog and pig. |
| UniProt ID: | P29474 |
| Gene/Protein Identifier: | 4846 (Entrez GeneID) |
| Species reactivity: | Human, Mouse, Rat Bovine, Dog, Porcine |
| Applications: | IHC |
| Recommended Dilutions/Conditions: | Immunohistochemistry (1:70) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Affinity purified. |
| Formulation: | Liquid. In PBS, pH 7.4, containing BSA and sodium azide. |
| Shipping: | Blue Ice Not Frozen |
| Long Term Storage: | +4°C |
| Scientific Background: | Nitric oxide (NO) is synthesized from L-arginine, oxygen, and NADPH by three known isoforms of heme-containing flavoproteins termed NO synthases (NOS I-III). Analysis of cDNA clones has identified three distinct NOS genes in mammals: neuronal (nNOS/NOS-I), endothelial (eNOS/NOS-III), and inducible (iNOS/NOS-II). eNOS and nNOS are constitutively expressed, agonist-triggered, Ca2+/calmodulin-dependent, and are inhibited by L-arginine analogues (L-NNA, L-NMMA). They are expressed in endothelium, adrenal glands, brain, and platelets. iNOS is inducible, Ca2+/calmodulin-independent, and also inhibited by NMMA and L-NNA. It is expressed in macrophages, hepatocytes, tumor cells, vascular smooth muscle and endothelial cells. |
| Regulatory Status: | RUO - Research Use Only |
Goat anti-rabbit IgG, polyclonal antibody (HRP conjugate) |
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| ELISA, IHC, WB | Print as PDF | ||||||
| ADI-SAB-300-J | 1 ml | 154.00 USD | |
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