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Cyclin E polyclonal antibody

ADI-905-372-1 1 ml 310.00 USD
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Product Specification

Alternative Name:CCNE
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human cyclin E.
UniProt ID:P24864
Gene/Protein Identifier:898 (Entrez GeneID)
Species reactivity:Human, Mouse
Recommended Dilutions/Conditions:Immunohistochemistry (1:50)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~50kDa by Western blot.
Purity Detail:Affinity purified.
Formulation:Liquid. In PBS, pH 7.4, containing BSA and sodium azide.
Shipping:Blue Ice Not Frozen
Long Term Storage:+4°C
Scientific Background:Cyclins are a family of proteins which function as the regulatory subunits of cyclin/cyclin-dependent kinase (Cdk) holoenzymes, mediating entry into and progression through the cell cycle. Each cyclin is expressed in a temporal fashion during the cell cycle, partnering with a specific Cdk to activate its protein kinase activity. The most well defined mitotic cyclins are: cyclin D, which partners with cdks 4 and 6 during early G1 phase; cyclin E, which activates Cdk2 in the G1 to S phase transition; cyclin A, which utilizes Cdks 1 and 2 during progression through S phase and into G2; and cyclin B, which activates Cdk1 in M-phase promotion.
905-372 IHC
Immunohistochemistry analysis of breast carcinoma stained with Cyclin E pAb.
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905-372 IHC

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