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BACE2 (NT) polyclonal antibody

 
ADI-905-290-100 100 µg 366.00 USD
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Product Specification

Alternative Name:β site APP cleaving enzyme, β-Secretase 2
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human BACE2.
 
UniProt ID:Q9Y5Z0
 
Species reactivity:Human, Mouse, Rat
 
Applications:IHC, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (10µg/ml)
Western Blot (0.5-1.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~70kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Scientific Background:Accumulation of the amyloid-beta (Abeta) plaque, which is linked with the pathogenesis of Alzheimer's disease, is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99 amino acid carboxy-terminal fragment (C99). beta-secretase was identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and Aspartyl protease 2 (Asp2). BACE/Asp2 is a transmembrane aspartic protease and colocalizes with approximately
 
905-290 WB
Western blot analysis of BACE2 in human (A) and mouse (B) heart tissue lysates with BACE2 antibody at 1µg/ml.
905-290 IHC
Immunohistochemistry analysis of BACE2 in mouse heart with BACE2 antibody at 10µg/ml.
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905-290 WB 905-290 IHC

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