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ADAM17 (CT) polyclonal antibody

ADI-905-249-100 100 µg 384.00 USD
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Product Specification

Alternative Name:TACE, A disintegrin and metalloproteinase 17
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human ADAM17.
UniProt ID:P78536
Species reactivity:Human, Mouse, Rat
Applications:ICC, WB
Recommended Dilutions/Conditions:Western Blot (1:500-1:2,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects bands of ~80 to ~130kDa (may represent mature protein, precursor, and glycosylated TACE) by Western blot.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:TNF-alpha converting enzyme (TACE) is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), and is responsible for the cleavage of membrane-bound precursor TNF-alpha to its mature, secreted form. TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP).
905-249 WB
Western blot analysis of TACE in HeLa and Jurkat whole cell lysate in the absence or presence of blocking peptide with TACE antibody at 1:500 dilution.
905-249 ICC
Immunocytochemistry analysis of TACE in HeLa cells with TACE antibody at 10µg/ml.
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905-249 WB 905-249 ICC

Product Literature References

High Glucose Upregulates ADAM17 through HIF-1α in Mesangial Cells: R. Li, et al.; J. Biol. Chem. 290, 21603 (2015), Application(s): Immunofluorescence, Abstract; Full Text

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