ADAM17 (CT), pAb



ADI-905-249-100	100 µg	260.00 USD

Product Specification

Alternative Name:	TACE, a disintegrin and metalloproteinase

Purity Detail:	Peptide affinity purified.

Formulation:	Liquid. In PBS containing 0.02% sodium azide.

Immunogen:	Synthetic peptide corresponding to the sequence near the C-terminus of human ADAM17.

Source/Host:	From rabbit.

Specificity:	Recognizes human, mouse and rat ADAM17. Detects bands of ~80 to ~130kDa (may represent mature protein, precursor, and glycosylated TACE) by Western blot.

Application:	Immunocytochemistry Western Blot (1:500-1:2000) Optimal conditions must be determined individually for each application.

Long Term Storage:	+4°C

Miscellaneous/General:	TNF-alpha converting enzyme (TACE) is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), and is responsible for the cleavage of membrane-bound precursor TNF-alpha to its mature, secreted form. TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP).

Western blot analysis of TACE in HeLa and Jurkat whole cell lysate in the absence or presence of blocking peptide with TACE antibody at 1:500 dilution.