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Bnip3L (IN) polyclonal antibody

 
ADI-905-185-100 100 µg 374.00 USD
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Product Specification

Alternative Name:BCL2/adenovirus E1B 19kDa interacting protein 3-like, NIX
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to aa 77-92 of human Bnip3L.
 
UniProt ID:O60238
 
Species reactivity:Human
 
Applications:IHC, WB
 
Recommended Dilutions/Conditions:Immunohistochemistry (2µg/ml)
Western Blot (0.5-1.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
 
Application Notes:Detects a band of ~40kDa by Western blot.
 
Purity Detail:Peptide affinity purified.
 
Formulation:Liquid. In PBS containing 0.02% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Bnip3L/Bnip3alpha/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. In particular, Bnip3L interacts with and overcomes the suppression of apoptosis mediated by Bcl-2 and Bcl-xL.
 
Bnip3L (IN) polyclonal antibody Immunohistochemistry
Immunohistochemistry analysis of human kidney tissue using Bnip3L antibody at 2µg/ml.
Bnip3L (IN) polyclonal antibody Western blot
Western blot analysis of Bnip3L in K562 whole cell lysate in the absence (A), or presence (B) of immunogenic peptide with Bnip3L antibody (IN) at 1µg/ml.
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Bnip3L (IN) polyclonal antibody Immunohistochemistry Bnip3L (IN) polyclonal antibody Western blot

Product Literature References

BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation: L.A. Brennan, et al.; Exp. Eye Res. 174, 173 (2018), Abstract;

General Literature References

Role of BNIP3 and NIX in cell death, autophagy, and mitophagy: J. Zhang & P.A. Ney; Cell Death Diff. 16, 939 (2009), Abstract;

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