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ASC polyclonal antibody

ADI-905-173-100 100 µg 381.00 USD
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Product Specification

Alternative Name:Apoptosis-associated speck-like protein containing a CARD, Caspase recruitment domain-containing protein 5, CARD-5, PYD and CARD domain-containing protein, PYCARD, Target of methylation-induced silencing, TMS1
Immunogen:Synthetic peptide corresponding to aa 182-195 of human ASC .
UniProt ID:Q9ULZ3
Species reactivity:Human
Applications:ICC, WB
Recommended Dilutions/Conditions:Western Blot (1µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~25kDa by Western blot.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:ASC (Apoptosis-associated speck-like protein containing a CARD domain) is a bipartite protein comprising two protein-protein interaction domains, a Pyrin domain (PYD) and a caspase recruitment domain (CARD). Proteins containing these domains play pivotal roles in regulating apoptosis and immune response pathways. Reported functions of ASC include apoptosis, activation of inflammatory caspases and regulation of NFκB.
905-173 WB
Western blot analysis of ASC in HL60 whole cell lysate in the absence (A) or presence (B) of blocking peptide (2287P) with ASC antibody at 1µg/ml.
905-173 ICC
Immunocytochemistry analysis of ASC in HL60 cells with ASC antibody at 5µg/ml.
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905-173 WB 905-173 ICC

Product Literature References

Danggui Buxue Tang Attenuates Tubulointerstitial Fibrosis via Suppressing NLRP3 Inflammasome in a Rat Model of Unilateral Ureteral Obstruction: L. Wang, et al.; BioMed. Res. Int. 2016, Article ID 9368483 (2016), Application(s): Western blot, Abstract; Full Text
Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages: E. Aflaki, et al.; Aging Cell 15, 77 (2016), Application(s): Immunoblotting, Abstract;
NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis: P. Varghese, et al.; J. Am. Heart. Assoc. 5, e003031 (2016), Application(s): Immunohistochemistry, Abstract; Full Text
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases: R.C. Coll, et al.; Nat. Med. 21, 248 (2015), Application(s): Western Blotting, Abstract;
Anti-Inflammatory Effect of Emodin via Attenuation of NLRP3 Inflammasome Activation: J. W. Han, et al.; Int. J. Mol. Sci. 16, 8102 (2015), Application(s): Western Blot, Abstract; Full Text
Estrogen suppresses hepatocellular carcinoma cells through ERβ-mediated upregulation of the NLRP3 inflammasome: Q. Wei, et al.; Lab. Invest. 95, 804 (2015), Application(s): Immunohistochemistry, Western Blot, Abstract;
Genipin suppresses NLRP3 inflammasome activation through uncoupling protein-2: V. Rajanbabu, et al.; Cell. Immunol. 297, 40 (2015), Application(s): Western Blot, Abstract;
Oligomerized CARD16 promotes caspase-1 assembly and IL-1β processing: T. Karasawa, et al.; FEBS Open Bio 5, 348 (2015), Application(s): Immunocyotochemistry, Abstract;
Role of NLRP3 Inflammasomes for Rhabdomyolysis-induced Acute Kidney Injury: T. Komada, et al.; Sci. Rep. 5, 10901 (2015), Application(s): Western Blot, Abstract; Full Text
Staphylococcus aureus Leukocidin A/B (LukAB) Kills Human Monocytes via Host NLRP3 and ASC when Extracellular, but Not Intracellular: J.H. Melehani, et al.; PLoS Pathog. 11, e1004970 (2015), Application(s): Western Blot, Abstract; Full Text
The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease: Y.H. Youm, et al.; Nat. Med. 21, 263 (2015), Application(s): Cell Culture, Western Blotting, Abstract;
Multiple binding sites on the ASC pyrin domain allow self-association and interaction with NLRP3: P.R. Vajjhala, et al.; J. Biol. Chem. 287, 41732 (2012), Application(s): Western-blotting using ASC-transfected HEK 293T cells, Abstract; Full Text
Varicella-zoster virus infection triggers formation of an interleukin-1β (IL-1β)-processing inflammasome complex: A.M. Nour, et al.; J. Biol. Chem. 286, 17921 (2011), Application(s): Western-blotting using human lung embryonic fibroblasts and human melanoma cells, Abstract; Full Text

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