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MMP-7 monoclonal antibody (2D3)

 
ADI-905-1013-0100 100 µg 399.00 USD
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Product Specification

Alternative Name:Matrix metalloproteinase 7, Matrilysin
 
Clone:2D3
 
Host:Mouse
 
Isotype:IgG
 
Immunogen:Recombinant protein corresponding to aa 18-267 of human MMP-7 (His-tagged).
 
UniProt ID:P09237
 
Gene/Protein Identifier:4316 (Gene ID)
 
Species reactivity:Human
 
Applications:ELISA, WB
 
Application Notes:Detects a band of ~29kDa by Western blot.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In 1X PBS, pH 7.4, containing 10% glycerol and 0.05% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:MMP-7 proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The MMP-7 enzyme degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
 
ADI-905-1013 WB
Western blot analysis of MMP-7 (human), (recombinant) (His-tag) probed with MMP-7, mAb (2D3) (Prod. No. ADI-905-1013) (lane 2). Lane 1 includes a representative MW Marker.
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ADI-905-1013 WB

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