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Matriptase monoclonal antibody (B12)

 
ADI-905-1007-0100 100 µg 399.00 USD
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Product Specification

Alternative Name:TADG-15, ST14
 
Clone:B12
 
Host:Mouse
 
Isotype:IgG
 
Immunogen:Recombinant protein corresponding to aa 619-854 of human matriptase (His-tagged).
 
UniProt ID:Q9Y5Y6
 
GenBank ID:6647302
 
Gene/Protein Identifier:6768 (Gene ID)
 
Species reactivity:Human
 
Applications:ELISA, WB
 
Application Notes:Detects a band of ~30kDa by Western blot.
 
Purity Detail:Protein G-affinity purified.
 
Formulation:Liquid. In 1X PBS, pH 7.4, containing 10% glycerol and 0.05% sodium azide.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:The protein encoded by the Matriptase gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion and metastasis.
 
ADI-905-1007 WB
Western blot analysis of Matriptase (human), (recombinant) (His-tag) (Prod. No. ADI-908-301) probed with Matriptase, mAb (D11) (Prod. No. ADI-905-1008) (lane 2) or Matriptase, mAb (B12) (Prod. No. ADI-905-1007) (lane 3). Lane 1 includes a representative MW Marker.
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ADI-905-1007 WB

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