2,3 dinor-6-keto-PGF_1α, pAb

Alternative Name:	Prostaglandin F1 α, PGF1

Formulation:	Liquid. Contains sodium azide.

Immunogen:	2,3-dinor-6-keto-Prostaglandin F1α conjugated to bovine serum albumin.

Source/Host:	From sheep.

Specificity:	Species independent.

Application:	EIA Optimal conditions must be determined individually for each application.

Long Term Storage:	-20°C

Miscellaneous/General:	6-keto-PGF1alpha is a stable hydrolysis product of prostacyclin (PGI2). Due to the short half-life of PGI2 in buffer (2-3 minutes) the production of prostacyclin is typically monitored by measurement of the 6-keto-PGF1alpha metabolite and its derivative in urine, 2,3-dinor-6-keto-PGF1alpha. PGI2 has autocoid functions that include platelet aggregation, inhibition of vasoconstrictor responses to pressor hormones, platelet anti- and disaggregatory properties, and reproductive functions. The effects are induced by receptor-mediated elevation of cAMP. Prostacyclin has clinical applications in atherosclerosis and protection from myocardial ischemia.