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KIM-1 (human) ELISA kit

Ultra sensitive (1.2 pg/ml) ELISA kit, enabling reduced input sample and matrix interference, for the quantification of KIM-1, an early biomarker for kidney injury or disease.
 
ADI-900-226-0001 96 wells 420.00 USD
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  • Sensitive – reliably measure as little as 1.2 pg/ml of KIM-1
  • High Throughput – results in <2 hours from up to 38 samples in duplicate
  • Specific – low cross-reactivity to similar proteins
  • Quantitative – fully quantitative results for both normal and disease state samples that surpass semi-quantitative Western blot analysis
The KIM-1 (human) ELISA kit is a complete, colorimetric, immunometric immunoassay kit for the quantitative determination of human KIM-1 in urine with results in <2 hours.
ADI-900-226 std curve
ADI-900-226 parallelism
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ADI-900-226 std curve ADI-900-226 parallelism ADI-900-226 box

Product Specification

Alternative Name:Kidney injury molecule-1, T-cell immunoglobulin and mucin domain-containing protein 1, TIMD-1, TIM-1, HAVCR1,  Hepatitis A virus cellular receptor 1
 
Sensitivity:1.279 pg/ml (range 7.813 - 500 pg/ml)
 
Assay Time:<2 hours
 
Applications:ELISA, Colorimetric detection
 
Application Notes:For the quantitative determination of human KIM-1 in urine.
 
Species reactivity:Human
 
Crossreactivity:No cross reactivity to similar molecules (< 0.02% TIM-3, TIM-4).
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Kit/Set Contains:Microtiter Plate, Assay Buffer, Standard, Antibody-conjugate, Streptavidin-HRP, TMB Substrate, Stop Solution, Wash Buffer Concentrate
 
Scientific Background:Chronic kidney disease (CKD) is a major public health problem, as one in nine American adults have CKD. There have been numerous studies focused on this disease over the years but there remains a need for improved therapeutics and identifying and/or predicting patient outcomes. One protein that has been identified as playing an important role in kidney disease is Kidney Injury Molecule-1 (KIM-1). KIM-1 is a 30KDa, type 1 membrane protein with an ectodomain that contains immunoglobulin and highly O-glycosylated mucin subdomains as well as multiple N-glycosylation sites. It is the most highly upregulated protein in the proximal tubule of the injured kidney. It exists in very low levels in normal kidneys but when upregulated during injury, it is detectable in urine in a wide variety of human diseases. KIM-1 is a potential biomarker for renal injury, which would suggest it has great importance in various kidney diseases and disorders, such as chronic kidney disease (as mentioned above), as well as acute tubular necrosis and acute kidney failure.
 
Technical Info/Product Notes:This product is licensed from the General Hospital Corporation and is protected by US patents 6,664,385 B1, 7,041,290 B2 and 7,696,321.
 
UniProt ID:Q96D42
 

Product Literature References

Estimation of kidney injury molecule-1 (Kim-1) in patients with lupus nephritis: Y. Nozaki, et al.; Lupus 23, 769 (2014), Abstract;
NGAL, L-FABP, and KIM-1 in comparison to established markers of renal dysfunction: L. Holzscheiter, et al.; Clin. Chem. Lab. Med. 52, 537 (2014), Abstract;
Nonalbuminuric proteinuria as a biomarker for tubular damage in early development of nephropathy with type 2 diabetic patients: S.S. Kim, et al.; Diabetes Metab. Res. Rev. 30, 736 (2014), Abstract;
Renal neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 expression in children with acute kidney injury and Henoch-Schönlein purpura nephritis: Y. Du, et al.; Exp. Ther. Med. 7, 1130 (2014), Abstract; Full Text
Serum and urinary NGAL but not KIM-1 raises in human postrenal AKI: A. Urbschat, et al.; Eur. J. Clin. Invest. 44, 652 (2014), Abstract;

General Literature References

Application of emerging biomarkers of acute kidney injury in development of kidney-sparing polypeptide-based antibiotics: D. Burt, et al.; Drug Chem. Toxicol. 37, 204 (2014), Abstract;

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