LVV Hemorphin 7 ELISA kit

Most sensitive and rapid LVV Hemorphin 7 kit for neuroscience market.

The LVV Hemorphin 7 EIA kit is a colorimetric, competitive immunoassay kit with results in just 3 hours.

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Sensitivity:	6.1 pg/ml (range 9.8 - 10,000 pg/ml)

Assay Time:	3 hours

Application:	For the quantitative determination of species independent LVV Hemorphin 7 in serum and tissue homogenate samples.

Crossreactivity:	LVV Hemorphin 7 (100%) and <0.003%: Leu-Valorphin-Arg (LVV Hemorphin-6), Valorphin, Angiotensin (1-12), Angiotensin I, Angiotensin (1-9), Angiotensin II, Angiotensin (1-7), Angiotensin A, Angiotensin III, Angiotensin IV

Use/Stability:	Store all components at +4ºC, except Standard at -20ºC.

Long Term Storage:	-20°C

Kit/Set Contains:	Microtiter Plate, Conjugate, Antibody, Assay Buffer 16, Wash Buffer Concentrate, Standard, TMB Substrate, Stop Solution 2, Streptavidin-HRP

Miscellaneous/General:	Hemorphins are opioid peptides derived by proteolysis from hemoglobin. Their sequences are identical in several mammalian species including human, sheep and bovine. LVV hemorphin 7 (LVVYPWTQRF) binds strongly to the Angiotensin IV (AT4) receptors in the brain. The AT4 receptor is an integral membrane aminopeptidase also known as IRAP (insulin regulated membrane aminopeptidase). LVV hemorphin 7 and AT4 are not substrates but rather inhibitors of the AT4 (IRAP) receptor. Both promote learning and memory and reverse amnesia in animal models. Elevated serum levels of LVV Hemorphin 7 have also been documented in patients with some forms of breast cancers that are associated with an increased expression of cathespins B and D.