- Sensitive - reliably measure as little as 6.1pg/ml of LVV Hemorphin 7
- Rapid - results in just 3 hours from up to 40 samples in duplicate
- Specific - low cross-reactivity to similar peptides
- Easy-to-use - liquid color-coded reagents reduce errors
The LVV Hemorphin 7 EIA kit is a colorimetric, competitive immunoassay kit with results in just 3 hours.
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Product Details
| Sensitivity: | 6.1 pg/ml (range 9.8 - 10,000 pg/ml) |
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| Assay Time: | 3 hours |
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| Applications: | ELISA, Colorimetric detection
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| Application Notes: | For the quantitative determination of species independent LVV Hemorphin 7 in serum and tissue homogenate samples. |
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| Wavelength: | 450 nm |
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| Species reactivity: | Species independent
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| Crossreactivity: | LVV Hemorphin 7 (100%) and <0.003%: Leu-Valorphin-Arg (LVV Hemorphin-6), Valorphin, Angiotensin (1-12), Angiotensin I, Angiotensin (1-9), Angiotensin II, Angiotensin (1-7), Angiotensin A, Angiotensin III, Angiotensin IV |
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| Use/Stability: | Store all components at +4ºC, except Standard at -20ºC. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Contents: | Microtiter Plate, Conjugate, Antibody, Assay Buffer 16, Wash Buffer Concentrate, Standard, TMB Substrate, Stop Solution 2, Streptavidin-HRP |
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| Scientific Background: | Hemorphins are opioid peptides derived by proteolysis from hemoglobin. Their sequences are identical in several mammalian species including human, sheep and bovine. LVV hemorphin 7 (LVVYPWTQRF) binds strongly to the Angiotensin IV (AT4) receptors in the brain. The AT4 receptor is an integral membrane aminopeptidase also known as IRAP (insulin regulated membrane aminopeptidase). LVV hemorphin 7 and AT4 are not substrates but rather inhibitors of the AT4 (IRAP) receptor. Both promote learning and memory and reverse amnesia in animal models. Elevated serum levels of LVV Hemorphin 7 have also been documented in patients with some forms of breast cancers that are associated with an increased expression of cathespins B and D. |
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| Regulatory Status: | RUO - Research Use Only |
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| Compatibility: | This product is compatible with the Absorbance 96 Plate Reader.
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Product Literature References
High-dose ferric citrate supplementation attenuates omega-3 polyunsaturated fatty acid biosynthesis via downregulating delta 5 and 6 desaturases in rats with high-fat diet-induced obesity: A. Faradina, et al.; Food Funct.
18, 11819 (2021),
Abstract;
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