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Angiotensin II ELISA kit

Highly sensitive ELISA, detecting as little as 4.6 pg/ml
 
ADI-900-204 96 wells 457.00 USD
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  • Highly specific with low cross-reactivity to similar peptides
  • Fully quantitative results that surpass semi-quantitative Western blot analysis
  • Easy-to-use liquid color-coded reagents reduce errors
  • Ready-to-use reagents and pre-coated plates reduce errors and save your time
The Angiotensin II EIA kit is a colorimetric, competitive immunoassay kit with results in 3.5 hours.
900-204 std curve2
900-204 dilutional linearity3
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900-204 std curve2 900-204 dilutional linearity3

Product Specification

Sensitivity:4.6 pg/ml (range 3.9-10,000 pg/ml)
 
Assay Time:3.5 hours
 
Applications:ELISA, Colorimetric detection
 
Application Notes:For the quantitative determination of species independent Angiotensin II in plasma and serum samples.
 
Species reactivity:Species independent
 
Crossreactivity:Angiotensin II (100%), Angiotensin A (100%), Angiotensin III (100%), Angiotensin IV (100%), Angiotensin I (0.319%), Angiotensin (1-9) (0.103%), LVV-hemorphin 7 (0.067%), Angiotensin (1-7) (0.053%), Bradykinin (0.022%)
 
Quantity:1 x 96-well plate
 
Use/Stability:Store all components at +4ºC, except Standard at -20ºC.
 
Shipping:Shipped on Blue Ice
 
Short Term Storage:-20°C
 
Long Term Storage:-20°C
 
Kit/Set Contains:Microtiter Plate, Conjugate, Antibody, Assay Buffer 16, Wash Buffer Concentrate, Standard, TMB Substrate, Stop Solution 2, Streptavidin-HRP
 
Scientific Background:Angiotensins are small peptides derived from angiotensinogen. Several of the known angiotensins are established endocrine effectors in the regulation of blood pressure, but they are also known to have other functions locally, in several organs and tissues (paracrine) and at the cellular level (autocrine / intracrine). Angiotensin I (DRVYIHPFHL) has no known effector function but it is an immediate precursor of Angiotensin II (DRVYIHPF). Angiotensin II binds AT1 receptors, which promote vasoconstriction, sodium retention, release of aldosterone, release of Arg-vasopressin, cell proliferation, inflammation, fibrosis, anxiety, and cardiac hypertrophy. Angiotensin A (ARVYIHPF), and Angiotensin III (RVYIHPF), also bind AT1 receptors. Angiotensin (1-7) (DRVYIHP) binds a different receptor called MAS-1 which has opposite effects (vasodilation, natriuresis, antiproliferation, NO release, PGE release, and apoptosis). Angiotensin IV (VYIHPF) binds yet another receptor called AT4 (IRAP), which promotes increase of blood flow, angiogenesis, and natriuresis, and which has also been implicated in memory formation and in the pathogenesis of Alzheimer’s disease. The peptide LVV-hemorphin-7 (LVVYPWTQRF), which is not an angiotensin, also binds the AT4 receptor. There are other angiotensin peptides that have been identified, including Ang (1-9) (DRVYIHPFH), Ang (1-12) (DRVYIHPFHLVI), Ang V(3-7) (VYIHP), as well as several other shorter peptides that have undetermined functions.
 
UniProt ID:P01019 (human)
 

Product Literature References

12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance: H.Z. Xu, et al.; Int. J. Mol. Sci. 17, E684 (2016), Application(s): Measurement of Angiotensin levels in rat, Abstract; Full Text
Endothelial actions of atrial natriuretic peptide prevent pulmonary hypertension in mice: F. Werner, et al.; Basic Res. Cardiol. 111, 22 (2016), Application(s): Measurement of lung immunoreactivity Angiotensin II, Abstract; Full Text
Oxidative stress increases the risk of pancreatic β cell damage in chronic renal hypertensive rats: S. Gao, et al.; Physiol. Rep. 4, e12900 (2016), Application(s): OGTT and plasma aldosterone levels, Abstract; Full Text
Angiotensin(1-7) and ACE2, “The Hot Spots” of Renin-Angiotensin System, Detected in the Human Aqueous Humor: M. Holappa, et al.; Open Ophthalmol. J. 9, 28 (2015), Application(s): ELISA using human aqueous humor samples , Abstract; Full Text
Arsenic causes aortic dysfunction and systemic hypertension in rats: Augmentation of angiotensin II signaling: P. Waghe, et al.; Chem. Biol. Interact. 237, 104 (2015), Application(s): ELISA using rat plasma, Abstract;
Attenuation of renovascular hypertension by cyclooxygenase-2 inhibitor partly through ANP release: B. M. Park, et al.; Peptides 69, 1 (2015), Application(s): ELISA using plasma, Abstract;
Neuronal over-expression of ACE2 protects brain from ischemia-induced damage: J. Chen, et al.; Neuropharmacology 79, 550 (2014), Application(s): Quantification of angiotensin II in murine plasma, Abstract;
Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions: J. Mittag, et al.; J. Clin. Invest. 123, 509 (2013), Application(s): ELISA using mouse serum, Abstract; Full Text
Effects of cardiac preload reduction and dobutamine on hepatosplanchnic blood flow regulation in porcine endotoxemia: S.M. Jakob, et al.; Am. J. Physiol. Gastrointest. Liver Physiol. 303, G247 (2012), Application(s): ELISA using pig plasma, Abstract; Full Text
Influence of angiotensin II type 1 receptor-associated protein on prenatal development and adult hypertension after maternal dietary protein restriction during pregnancy: K. Tsukuda, et al.; J. Am. Soc. Hypertens. 6, 324 (2012), Application(s): ELISA using mouse plasma, Abstract;

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