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Big Endothelin-1 (rat), ELISA kit

 
ADI-900-073 96 wells 746.00 USD
Do you need bulk/larger quantities?
 
  • Measure low levels of rat Big ET-1
  • Convenient 4°C storage
  • Assay up to 38 samples in duplicate per plate
The Big Endothelin-1 (rat), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results overnight + 1 hour.
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Product Specification

Alternative Name:Big ET-1
 
Sensitivity:0.72 pg/ml (range 0.78 - 100 pg/ml)
 
Assay Time:Overnight + 1 hour
 
Applications:ELISA, Colorimetric detection
 
Application Notes:For the quantitative determination of rat Big ET-1 in culture supernatants, plasma, and serum.
 
Species reactivity:Rat
 
Shipping:Blue Ice Not Frozen
 
Long Term Storage:+4°C
 
Kit/Set Contains:Microtiter plate, Labeled antibody concentrate, Antibody diluent, Assay buffer, Wash buffer concentrate, Standard, TMB Substrate, Stop solution
 
Scientific Background:Endothelins (ET) are isopeptides produced by vascular endothelium that have potent vasoconstrictive activity. The peptides are encoded by three separate genes and processed to yield 39-residue "Big ET" molecules which are further processed to the 21 amino acid sequences designated ET-1, ET-2 and ET-3. ET action is mediated via binding to two receptors, ETA and ETB. Activation of ETA increases vasoconstriction and sodium retention, thereby increasing blood pressure. Activation of ETB receptors triggers the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells and increases urine production and elimination, thereby lowering blood pressure.
 
UniProt ID:P22388
 

Product Literature References

Consequences of a Maternal High-Fat Diet and Late Gestation Diabetes on the Developing Rat Lung: M.L. Baack, et al.; PLoS One 11, e0160818 (2016), Application(s): Milliplex assays performed on lung lysate, Abstract; Full Text
Endothelin-1 induces LIMK2-mediated programmed necrotic neuronal death independent of NOS activity: A.R. Ko, et al.; Mol. Brain 8, 58 (2015), Application(s): ELISA measuring ET-1 in rats , Abstract; Full Text
Value of Caffeic Acid Phenethyl Ester Pretreatment in Experimental Sepsis Model in Rats: O. Alici, et al.; Mediators Inflamm. 2015, 810948 (2015), Application(s): ELISA using rat serum, Abstract; Full Text

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