Big Endothelin-1 (human), EIA kit

ADI-900-022

Revised 27-Jan-10

Big Endothelin-1 (human), EIA kit
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	Endothelins [ETs] & Endothelin Receptors / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ADI-900-022		96 wells	495.00 USD

Product Specification

SENSITIVITY:	0.23 pg/ml (range 0.78 - 100 pg/ml)
KIT/SET CONTAINS:	Microtiter plate, Labeled antibody concentrate, Antibody diluent, Assay buffer, Wash buffer concentrate, Standard, TMB Substrate, Stop solution
APPLICATION:	For the quantitative determination of human Big ET-1 in culture supernatants and serum.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C

Product Images

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Product Description

The Big Endothelin-1 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results overnight + 1 hour..

General Information

Endothelins (ET) are isopeptides produced by vascular endothelium that have potent vasoconstrictive activity. The peptides are encoded by three separate genes and processed to yield 39-residue "Big ET" molecules which are further processed to the 21 amino acid sequences designated ET-1, ET-2 and ET-3. ET action is mediated via binding to two receptors, ET_A and ET_B. Activation of ET_A increases vasoconstriction and sodium retention, thereby increasing blood pressure. Activation of ET_B receptors triggers the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells and increases urine production and elimination, thereby lowering blood pressure.
BACKGROUND/TECHNICAL INFORMATION
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