Big Endothelin-1 (human), EIA kit



ADI-900-022	96 wells	495.00 USD

The Big Endothelin-1 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results overnight 1 hour..

Product Specification

Sensitivity:	0.23 pg/ml (range 0.78 - 100 pg/ml)

Kit/Set Contains:	Microtiter plate, Labeled antibody concentrate, Antibody diluent, Assay buffer, Wash buffer concentrate, Standard, TMB Substrate, Stop solution

Application:	For the quantitative determination of human Big ET-1 in culture supernatants and serum.

Shipping:	SHIPPED ON BLUE ICE

Long Term Storage:	+4°C

Miscellaneous/General:	Endothelins (ET) are isopeptides produced by vascular endothelium that have potent vasoconstrictive activity. The peptides are encoded by three separate genes and processed to yield 39-residue "Big ET" molecules which are further processed to the 21 amino acid sequences designated ET-1, ET-2 and ET-3. ET action is mediated via binding to two receptors, ET_A and ET_B. Activation of ET_A increases vasoconstriction and sodium retention, thereby increasing blood pressure. Activation of ET_B receptors triggers the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells and increases urine production and elimination, thereby lowering blood pressure.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

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Product Literature References

Endothelin-1 Is Induced by Cytokines in Human Vascular Smooth Muscle Cells: Evidence for Intracellular Endothelin-Converting Enzyme: M. Woods, et al. ; Mol. Pharmacol. 55, 902 (1999), Application(s): EIA using human culture supernatants, Abstract;

Elevated immunoreactive endothelin-1 levels in newborn rabbit lungs after meconium aspiration: A. Zagariya, et al. ; Pediatr. Crit. Care Med. 3, 297 (2002), Application(s): EIA using rabbit lung lavage fluid, Abstract;