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Big Endothelin-1 (human), EIA kit

 
ADI-900-022 96 wells 495.00 USD
 
The Big Endothelin-1 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results overnight 1 hour..

Product Specification

Sensitivity:0.23 pg/ml (range 0.78 - 100 pg/ml)
 
Kit/Set Contains:Microtiter plate, Labeled antibody concentrate, Antibody diluent, Assay buffer, Wash buffer concentrate, Standard, TMB Substrate, Stop solution
 
Application:For the quantitative determination of human Big ET-1 in culture supernatants and serum.
 
Shipping:SHIPPED ON BLUE ICE
 
Long Term Storage:+4°C
 
Miscellaneous/General:Endothelins (ET) are isopeptides produced by vascular endothelium that have potent vasoconstrictive activity. The peptides are encoded by three separate genes and processed to yield 39-residue "Big ET" molecules which are further processed to the 21 amino acid sequences designated ET-1, ET-2 and ET-3. ET action is mediated via binding to two receptors, ETA and ETB. Activation of ETA increases vasoconstriction and sodium retention, thereby increasing blood pressure. Activation of ETB receptors triggers the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells and increases urine production and elimination, thereby lowering blood pressure.
 
Background / Technical Information:Please click here for the comprehensive product datasheet.
 
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Product Literature References

Endothelin-1 Is Induced by Cytokines in Human Vascular Smooth Muscle Cells: Evidence for Intracellular Endothelin-Converting Enzyme: M. Woods, et al. ; Mol. Pharmacol. 55, 902 (1999), Application(s): EIA using human culture supernatants, Abstract;
Elevated immunoreactive endothelin-1 levels in newborn rabbit lungs after meconium aspiration: A. Zagariya, et al. ; Pediatr. Crit. Care Med. 3, 297 (2002), Application(s): EIA using rabbit lung lavage fluid, Abstract;

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