The PGE2 EIA kit is a colorimetric competitive enzyme immunoassay kit with results in < 3 hours. Absorbance is read at 405 nm. Screen inhibitors of COX II activity by measuring the levels of downstream PGE2. Commercially available since 1992, this kit is widely cited in peer-reviewed publications. The non-radioactive ready-to-use liquid color-coded reagents reduce errors.
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Product Details
Alternative Name:
Prostaglandin E2
Sensitivity:
13.4 pg/ml (range 39.1 - 2,500 pg/ml)
Assay Time:
<3 hours
Applications:
ELISA, Colorimetric detection
Application Notes:
For the quantitative determination of PGE2 in culture supernatants, serum, saliva, urine, and whole blood from any species. Cited sample types include cerebral spinal fluid, dialysate, gingival crevicular fluid, peritoneal exudate fluid and peritoneal exudate cell supernatant, plasma, and tissue.
Wavelength:
405 nm
Species reactivity:
Species independent
Use/Stability:
Store all components at +4°C, except standard and conjugate at -20°C.
Prostaglandin E2 (PGE2) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis. Oxidation of arachidonic acid by prostaglandin synthases (COX-1 and COX-2) produces prostaglandin H2 (PGH2), which is further metabolized by PGE synthases into its major product, PGE2. PGE2 mediates autocrine and paracrine signaling by binding to G-protein coupled receptors (EP1, EP2, EP3, EP4) on the cell surface, functioning to modulate phospholipase C and adenylate cyclase activity. PGE2 has been of great interest as a therapeutic target, either by modulation of its synthesis by COX inhibitors (NSAIDS) or by modulation of its receptors by downregulation or binding antagonists. PGE2 production in a variety of tissues has been shown to modulate numerous physiological processes including natriuresis in the kidney, smooth muscle elasticity in the vasculature, and the inflammatory response to damaged tissues by monocytes and macrophages.
Cinnamic aldehyde, an anti-inflammatory component in Du-Huo-Ji-Sheng-Tang, ameliorates arthritis in II collagenase and monosodium iodoacetate induced osteoarthritis rat models: S.H. Tseng, et al.; J. Tradit. Complement. Med. 13, 51 (2023), Abstract;
Comparing the Effects of Rocaglates on Energy Metabolism and Immune Modulation on Cells of the Human Immune System: S. Schiffmann, et al.; Int. J. Mol. Sci. 24, 5872 (2023), Abstract;
Effects of 2-carba-cyclic phosphatidic acid derivatives on IL-1β-stimulated human chondrocytes: M. Yoshii, et al.; Prostaglandins Other Lipid Mediat. 164, 106699 (2023), Abstract;
Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer’s disease: S.M. Wang, et al.; Heliyon 9, e15406 (2023), Abstract;
Genomic analysis in the colon tissues of omega-3 fatty acid-treated rats identifies novel gene signatures implicated in ulcerative colitis: J. Magisetty, et al.; Int. J. Biol. Macromol. 258, 128867 (2023), Abstract;
Glycolipid-enriched fraction of Osmanthus fragrans inhibits LPS-induced expression of inflammatory genes, COX-2, E-selectin, and Interleukin-8: T. Pirker, et al.; J. Ethnopharmacol. 309, 116328 (2023), Abstract;
In vitro and in silico studies of 7′′,8′′-buddlenol D anti-inflammatory lignans from Carallia brachiata as p38 MAP kinase inhibitors: N. Nalinratana, et al.; Sci. Rep. 13, 3558 (2023), Abstract;
In vitro and in vivo anti-osteoarthritis effects of tradition Chinese prescription Ji-Ming-San: C.Y. Hsieh, et al.; J. Ethnopharmacol. 305, 116084 (2023), Abstract;
Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes: A. Gainullina, et al.; Cell Rep. 42, 112046 (2023), Abstract;
PGE2 expression by HPV6/11-induced respiratory papillomas blocks NK cell activation in patients with recurrent respiratory papillomatosis: M. Israr, et al.; Eur. J. Immunol. 53, e2250036 (2023), Abstract;
UHPLC-MS Phytochemical Profiling and Insight into Bioactivity of Rabelera holostea (Greater Stitchwort) Extract: J.S.K. Stanković, et al.; Molecules 28, 1274 (2023), Abstract;
A safety evaluation of allogeneic freeze-dried platelet-rich plasma or conditioned serum compared to autologous frozen products equivalents in equine healthy joints: L.C. Garbin, et al.; BMC Vet. Res. 18, 141 (2022), Abstract;
Antiproliferative Activity of Buddleja saligna (Willd.) against Melanoma and In Vivo Modulation of Angiogenesis: D. Twilley, et al.; Pharmaceuticals 15, 1497 (2022), Abstract;
Danger signal extracellular calcium initiates differentiation of monocytes into SPP1/osteopontin-producing macrophages: S. Murthy, et al.; Cell Death Dis. 13, 53 (2022), Abstract;
Delta-9-tetrahydrocannabinol increases vascular endothelial growth factor (VEGF) secretion through a cyclooxygenase-dependent mechanism in rat granulosa cells: A.A.M. Peña, et al.; Reprod. Toxicol. 111, 59 (2022), Abstract;
Dual inhibition of SGLT2 and DPP-4 promotes natriuresis and improves glomerular hemodynamic abnormalities in KK/Ta-Ins2Akita mice with progressive diabetic kidney disease: H. Fujita, et al.; Biochem. Biophys. Res. Commun. 635, 84 (2022), Abstract;
Functional rewiring of G protein-coupled receptor signaling in human labor: A.R. Walker, et al.; Cell Rep. 40, 36070698 (2022), Abstract;
Gestational NSAIDs distinctly reprogram cardiac injury in preeclamptic rats: Roles of cyclooxygenase, apoptotic and autophagic trails: M.A. Ali, et al.; Life Sci. 310, 121130 (2022), Abstract;
Human MuStem cells repress T-cell proliferation and cytotoxicity through both paracrine and contact-dependent pathways: M. Charrier, et al.; Stem Cells Res. Ther. 13, 7 (2022), Abstract;
Immune-modulation effect of Halocynthia aurantium tunic lipid on RAW264.7 cells: A.Y. Jang, et al.; Food Sci. Biotechnol. 31, 101 (2022), Abstract;
In vitro, in vivo and in silico evaluation of the anti-inflammatory potential of Hyssopus officinalis L. subsp. aristatus (Godr.) Nyman (Lamiaceae): T. Mićović , et al.; J. Ethnopharmacol. 293, 115201 (2022), Abstract;
Infection of Galleria mellonella (lepidoptera) larvae with the entomopathogenic fungus Conidiobolus coronatus (entomophthorales) induces apoptosis of hemocytes and affects the concentration of eicosanoids in the hemolymph: A.K. Wronska, et al.; Front. Physiol. 12, 774086 (2022), Application(s): ELISA kit using hemolymph, Abstract; Full Text
Label-Free, Novel Electrofluidic Capacitor Biosensor for Prostaglandin E2 Detection toward Early and Rapid Urinary Tract Infection Diagnosis: A. Ganguly, et al.; ACS Sens. 7, 186 (2022), Abstract;
Molecular Mechanism of Cinnamomum cassia against Gastric Damage and Identification of Active Compounds: M.J. Lee, et al.; Biomolecules 12, 525 (2022), Abstract;
NFκB inhibition to lift the mechano-competence of mesenchymal stromal cell-derived neocartilage toward articular chondrocyte levels: J. Lückgen, et al.; Stem Cell Res. Ther. 13, 168 (2022), Abstract;
Novel Perceptions on Chemical Profile and Biopharmaceutical Properties of Mentha spicata Extracts: Adding Missing Pieces to the Scientific Puzzle: G. Zengin, et al.; Plants (Basel) 11, 233 (2022), Abstract;
Participation of lipopolysaccharide in hyperplasic adipose expansion: Involvement of NADPH oxidase/ROS/p42/p44 MAPK-dependent Cyclooxygenase-2: C.C. Chang, et al.; J. Cell. Mol. Med. 26, 3850 (2022), Abstract;
Prostaglandin E2–Induced AKT Activation Regulates the Life Span of Short-Lived Plasma Cells by Attenuating IRE1α Hyperactivation: W. Wang, et al.; J. Immunol. 208, 1912 (2022), Abstract;
Salivary inflammatory mediators as biomarkers for oral mucositis and oral mucosal dryness in cancer patients: A pilot study: A. Kiyomi, et al.; PLoS One 17, e0267092 (2022), Abstract;
Specialized Pro-Resolving Mediators Do Not Inhibit the Synthesis of Inflammatory Mediators Induced by Tumor Necrosis Factor-α in Synovial Fibroblasts: Y. Sueda, et al.; Yonoago Acta Med. 65, 111 (2022), Abstract;
The ethanolic extract of Curcuma longa grown in Korea exhibits anti-neuroinflammatory effects by activating of nuclear transcription factor erythroid-2-related factor 2/heme oxygenase-1 signaling pathway: K. Kim, et al.; BMC Complement Med. Ther. 22, 343 (2022), Abstract;
A Novel Class of Dual-Acting DCH-CORMs Counteracts Oxidative Stress-Induced Inflammation in Human Primary Tenocytes: F. Appetecchia, et al.; Antioxidants 10, 1828 (2021), Abstract;
Anticancer Effects of Helminthostachys zeylanica Ethyl acetate Extracts on Human Gastric Cancer Cells through Downregulation of the TNF-α-activated COX-2-cPLA2-PGE2 Pathway: M.M. Tsai, et al.; J. Cancer 12, 7052 (2021), Abstract;
Anticancer profile and anti-inflammatory effect of new N-(2-((4-(1,3-diphenyl-1H-pyrazol-4-yl)pyridine sulfonamide derivatives: M.S. Abdel-Maksoud, et al.; Bioorg. Chem. 117, 105424 (2021), Abstract;
Antioxidants and/or fish oil reduce intermittent hypoxia-induced inflammation in the neonatal rat terminal ileum: G. Mustafa, et al.; Prostaglandins Other Lipid Mediat. 155, 106565 (2021), Abstract;
Assessment of Anti-Inflammatory and Antioxidant Effects of Citrus unshiu Peel (CUP) Flavonoids on LPS-Stimulated RAW 264.7 Cells: A. Karthikeyan, et al.; Plants 10, 2209 (2021), Abstract;
Discovery of N-amido-phenylsulfonamide derivatives as novel microsomal prostaglandin E 2 synthase-1 (mPGES-1) inhibitors: M. Kim, et al.; Bioorg. Med. Chem. Lett. 41, 127992 (2021), Abstract;
Effect of mesenchymal stem cells combined with chondroitin sulfate in an in vitro model of osteoarthritis: S. Pérez-Castrillo, et al.; Am. J. Transl. Res. 13, 5928 (2021), Abstract;
Leptin reduces in vitro cementoblast mineralization and survival as well as induces PGE2 release by ERK1/2 commitment: G. Ruiz-Heiland, et al.; Clin. Oral. Investig. 25, 1933 (2021), Abstract; Full Text
Potential Surrogate Quantitative Immunomodulatory Potency Assay for Monitoring Human Umbilical Cord-derived Mesenchymal Stem Cells Production: S. Teng, et al.; Cell Biol. Int. 45, 1072 (2021), Abstract;
Synergistic effect of Korean red ginseng extract and GABA mixture on the IgE production in mice via Th1/Th2 cell balance: J.S. Lim, et al.; Food Sci. Biotechnol. 30, 1571 (2021), Abstract;
The inhibitory effect of AMP-activated protein kinase (AMPK) on chemokine and prostaglandin production in human endometrial stromal cells: Y. Kawano, et al.; Reprod. Biol. Endocrinol. 19, 188 (2021), Abstract;
CoCrMo surface modifications affect biocompatibility, adhesion, and inflammation in human osteoblasts: B. Lohberger, et al.; Sci. Rep. 10, 1682 (2020), Abstract; Full Text
Genetic deletion of connexin 37 causes polyuria and polydipsia: J. Xue, et al.; PLoS One 15, e0244251 (2020), Abstract; Full Text
Hypoxia-preconditioned mesenchymal stem cells prevent renal fibrosis and inflammation in ischemia-reperfusion rats: N. Ishiuchi, et al.; Stem Cell Res. Ther. 11, 130 (2020), Abstract; Full Text
Interleukin-1 receptor-induced PGE2 production controls acetylcholine-mediated cardiac dysfunction and mortality during scorpion envenomation: M.B. Reis, et al.; Nat. Commun. 11, 5433 (2020), Abstract; Full Text
Apolipoprotein D overexpression alters hepatic prostaglandin and omega fatty acid metabolism during the development of a non-inflammatory hepatic steatosis: F. Desmarais, et al.; Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1864, 522 (2019), Application(s): ELISA using liver homogenates, Abstract;
Baltic amber teething necklaces: could succinic acid leaching from beads provide anti-inflammatory effects?: M.D. Nissen, et al.; BMC Complement. Altern. Med. 19, 162 (2019), Abstract;
IRE1α-XBP1 signaling in leukocytes controls prostaglandin biosynthesis and pain: S. Chopra, et al.; Science 365, eaau6499 (2019), Application(s): Cell Culture Supernatant, Abstract;
Mechanisms utilized by feline adipose-derived mesenchymal stem cells to inhibit T lymphocyte proliferation: N. Taechangam, et al.; Stem Cell Res. Ther. 10, 188 (2019), Abstract; Full Text
Molecular profiling and functional analysis of macrophage-derived tumor extracellular vesicles: C. Cianciaruso, et al.; Cell Rep. 27, 3062 (2019), Application(s): ELISA using culture supernatants, Abstract; Full Text
Olive-Derived Hydroxytyrosol Shows Anti-inflammatory Effect without Gastric Damage in Rats: Y. Yonezawa, et al.; Biol. Pharm. Bull. 42, 1120 (2019), Abstract;
Redox Control of IL-6-Mediated Dental Pulp Stem-Cell Differentiation on Alginate/Hydroxyapatite Biocomposites for Bone Ingrowth: S. Sancilio, et al.; Nanomaterials (Basel) 9, 1656 (2019), Abstract; Full Text
The serine protease inhibitors and SERPINE1/2 disrupt prostaglandin E2 production and hyaluronic acid retention in FSH‐stimulated pig cumulus–oocyte complexes: M. Blaha, et al.; Reprod. Domest. Anim. 54, 65 (2019), Application(s): Cell culture supernatant from porcine cumulus-oocyte complexes, Abstract;
An ethanol extract of the rhizome of Atractylodes chinensis exerts anti-gastritis activities and inhibits Akt/NF-κB signaling: M.J. Hossen, et al.; J. Ethnopharmacol. 228, 18 (2018), Abstract;
Anti-neuroinflammatory effects of GPR55 antagonists in LPS-activated primary microglial cells: S.W. Saliba, et al.; J. Neuroinflammation 15, 322 (2018), Abstract; Full Text
Carbon monoxide ameliorates Staphylococcus aureus-elicited COX-2/IL-6/MMP-9-dependent human aortic endothelial cell migration and inflammatory responses: M.H. Tsai, et al.; Immunol. Lett. 203, 40 (2018), Abstract;
Carbon monoxide releasing molecule-2 attenuates Pseudomonas aeruginosa-induced ROS-dependent ICAM-1 expression in human pulmonary alveolar epithelial cells: C.W. Lee, et al.; Redox Biol. 18, 93 (2018), Abstract; Full Text
Dietary Supplementation With ω6 LC-PUFA-Rich Algae Modulates Zebrafish Immune Function and Improves Resistance to Streptococcal Infection: S. Nayak, et al.; Front. Immunol. 9, 1960 (2018), Application(s): Zebrafish kidney lysates, Abstract; Full Text
Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase: H. Pein, et al.; Nat. Commun. 9, 3834 (2018), Application(s): Peritoneal exudates, Abstract; Full Text
Ketoprofen affects the mammary immune response in dairy cows in vivo and in vitro: D. Dan, et al.; J. Dairy Sci. 101, 11321 (2018), Abstract;
Prostaglandin E2 secreted from feline adipose tissue-derived mesenchymal stem cells alleviate DSS-induced colitis by increasing regulatory T cells in mice: J.H. An, et al.; BMC Vet. Res. 14, 354 (2018), Abstract; Full Text
Synthetic 3',4'-Dihydroxyflavone Exerts Anti-Neuroinflammatory Effects in BV2 Microglia and a Mouse Model: N. Kim, et al.; Biomol. Ther. (Seoul) 26, 210 (2018), Abstract; Full Text
Anti-inflammatory effect of lycopene in SW480 human colorectal cancer cells: J.H. Cha, et al.; Nutr. Res. Pract. 11, 90 (2017), Abstract; Full Text
Colon cancer-derived myofibroblasts increase endothelial cell migration by glucocorticoid-sensitive secretion of a pro-migratory factor: Z. Drebert, et al.; Vascul. Pharmacol. 89, 19 (2017), Application(s): Determine the concentrations of prostanoids in conditioned medium from myofibroblasts and HUVECs, and in HUVEC lysates, Abstract;
Differential Effects of sEH Inhibitors on the Proliferation and Migration of Vascular Smooth Muscle Cells: H.S. Kim, et al.; Int. J. Mol. Sci. 18, 2683 (2017), Abstract; Full Text
Expression of toll-like receptor-1 by bradykinin in human gingival fibroblasts: J.A. Arreguin-Cano T; Int. J. Clin. Exp. Pathol. 10, 1283 (2017), Application(s): Measurement of PGE2 in supernatant., Full Text
Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome: H.C. Clark, et al.; Stem Cell Res. Ther. 8, 69 (2017), Application(s): Measurement of PGE2 in supernatant of human and feline cells., Abstract; Full Text
Inhibitory effects of Aconiti Lateralis Radix Preparata on chronic intermittent cold-induced inflammation in the mouse hypothalamus: W. Kim, et al.; J. Ethnopharmacol. 215, 27 (2017), Abstract;
Mast cell degranulation and calcium influx are inhibited by an Echinacea purpurea extract and the alkylamide dodeca-2E, 4E-dienoic acid isobutylamide: T.V. Gulledge, et al.; J. Ethnopharmacol. 212, 166 (2017), Abstract;
Monoacylglycerol lipase inhibitor JZL184 prevents HIV-1 gp120-induced synapse loss by altering endocannabinoid signaling: X. Zhang, et al.; Neuropharmacology 128, 269 (2017), Abstract;
Novel augmentation by bufalin of protein kinase C-induced cyclooxygenase-2 and IL-8 production in human breast cancer cells: H.T. Chen, et al.; Innate Immun. 23, 54 (2017), Abstract; Full Text
Prostaglandin E2 stimulates the expression of cumulus expansion-related genes in pigs: the role of protein kinase B: M. Blaha, et al.; Prostaglandins Other Lipid Mediat. 130, 38 (2017), Application(s): ELISA using pig samples, Abstract;
The effect of intra-articular botulinum toxin A on substance P, prostaglandin E2, and tumor necrosis factor alpha in the canine osteoarthritic joint: H.M. Heikkilä, et al.; BMC Vet. Res. 13, 74 (2017), Application(s): Canine synovial fluid and serum, Abstract; Full Text
A positive feedback loop between progesterone and microsomal prostaglandin E synthase-1-mediated PGE2 promotes production of both in mouse granulosa cells: K. Tamura, et al.; Prostaglandins Other Lipid Mediat. 123, 56 (2016), Application(s): Measurement of PGE2 in the culture media, Abstract;
Anti-inflammatory effects of 6′-O-acetyl mangiferin from Iris rossii Baker via NF-κb signal blocking in lipopolysaccharide-stimulated RAW 264.7 cells: J.H. Jang, et al.; Chem. Biol. Interact. 2797, 30303 (2016), Application(s): Determination of PGE2 production, Abstract;
Dimethyl fumarate activates the prostaglandin EP2 receptor and stimulates cAMP signaling in human peripheral blood mononuclear cells: S.E. Fiedler, et al.; Biochem. Biophys. Res. Commun. 475, 19 (2016), Application(s): Supernatant PGE2 was measured, Abstract;
Directly interact with Keap1 and LPS is involved in the anti-inflammatory mechanisms of (-)-epicatechin-3-gallate in LPS-induced macrophages and endotoxemia: Y.S. Chiou, et al.; Free. Radic. Biol. Med. 94, 1 (2016), Application(s): Measurement of prostaglandin E2 (PGE2) level in culture medium, Abstract;
Effects of Almond- and Olive Oil-Based Docosahexaenoic- and Vitamin E-Enriched Beverage Dietary Supplementation on Inflammation Associated to Exercise and Age: X. Capo, et al.; Nutrients 8, 619 (2016), Application(s): Cytokine, Eicosanoids and Adhesion Molecules Determination, plasma, Abstract; Full Text
Enhanced anti-inflammatory activity of brown seaweed Laminaria japonica by fermentation using Bacillus subtilis: H.T.V. Lin, et al.; Process Biochem. 51, 1945 (2016), Application(s): Measurement of prostaglandin E2 (PAGE2), cell supernatant,
Enhanced biocompatible and hemocompatible nano/micro porous surface as a biological scaffold for functionalizational and biointegrated implants: S.F. Chu, et al.; J. Alloys Compd. 684, 726 (2016),
Evaluation of anti-acne properties of phloretin in vitro and in vivo: H. Kum, et al.; Int. J. Cosmet. Sci. 38, 85 (2016), Application(s): HaCaT cell culture supernatant, Abstract;
Grid-like surface structures in thermoplastic polyurethane induce anti-inflammatory and anti-fibrotic processes in bone marrow-derived mesenchymal stem cells: Y. Roger, et al.; Colloids Surf. B Biointerfaces 148, 104 (2016), Application(s): ELISA using human bone marrow-derived mesenchymal stem cell supernatant, Abstract;
Hypoxia-mediated impaired erythrocyte Lands' Cycle is pathogenic for sickle cell disease: H. Wu, et al.; Sci. Rep. 6, 29637 (2016), Application(s): ELISA using mouse plasma, Abstract; Full Text
Implantation and pregnancy outcome of Sprague-Dawley rats fed with low and high salt diet: G.O. Oludare, et al.; Middle East Fertil. Soc. J. 21, 228 (2016), Application(s): Measured rat serum PGE2 levels,
In vitro bioactive properties of phlorotannins recovered from hydrothermal treatment of Sargassum muticum: M.P. Casas, et al.; Sep. Purif. Technol. 167, 117 (2016), Application(s): Determination of the amount of PGE2 in thawed plasma supernatants,
Isolation and Identification of a Flavone Apigenin from Marine Red Alga Acanthophora spicifera with Antinociceptive and Anti-Inflammatory Activities: G.A. El Shoubaky, et al.; J. Exp. Neurosci. 10, 21 (2016), Application(s): TNF-α measured in mouse blood samples, Abstract; Full Text
Local intra-uterine Ang-(1-7) infusion attenuates PGE2 and 6-keto PGF1α in decidualized uterus of pseudopregnant rats: K.B. Brosnihan, et al.; Reprod. Biol. Endocrinol. 14, 68 (2016), Application(s): Assaying tissue extracts, Abstract; Full Text
MRI-Based Assessment of Intralesional Delivery of Bone Marrow-Derived Mesenchymal Stem Cells in a Model of Equine Tendonitis: A. Scharf, et al.; Stem Cells Int. 2016, 1 (2016), Application(s): Assessing the ability of MSCs to modulate the inflammatory response, Abstract; Full Text
Resokaempferol-mediated anti-inflammatory effects on activated macrophages via the inhibition of JAK2/STAT3, NF-κB and JNK/p38 MAPK signaling pathways: Q. Yu, et al.; Int. Immunopharmacol. 38, 104 (2016), Application(s): PGE2 was measured in mouse supernatant, Abstract;
The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation: X. Wang, et al.; PLoS One 12, e1005803 (2016), Application(s): PGE2 measurement in cell lysates, Abstract; Full Text
Uterus-targeted liposomes for preterm labor management: studies in pregnant mice: J.S. Refuerzo, et al.; Sci. Rep. 6, 34710 (2016), Abstract; Full Text
Antagonizing Effects of Aspartic Acid against Ultraviolet A-Induced Downregulation of the Stemness of Human Adipose Tissue-Derived Mesenchymal Stem Cells: K. Jung, et al.; PLoS One 10, e0124417 (2015), Application(s): ELISA using human culture supernatant , Abstract; Full Text
Anti-inflammatory effect of desoxo-narchinol-A isolated from Nardostachys jatamansi against lipopolysaccharide: J.Y. Shin, et al.; Int. Immunopharmacol. 29, 730 (2015), Application(s): PGE2 level was measured by ELISA in mice, Abstract;
Apolipoprotein D Transgenic Mice Develop Hepatic Steatosis through Activation of PPAR? and Fatty Acid Uptake: M. Labrie, et al.; PLoS One 10, e0130230 (2015), Abstract; Full Text
Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney: L. Pelligand, et al.; BMC Vet. Res. 11, 296 (2015), Abstract; Full Text
Effectiveness of the combinational treatment of Laminaria japonica and Cistanche tubulosa extracts in hair growth: K. Shin, et al.; Lab. Anim. Res. 31, 24 (2015), Application(s): ELISA using mouse exudate, Abstract; Full Text
Insight into the molecular mechanism of an herbal injection by integrating network pharmacology and in vitro: Y.M. Ma, et al.; J. Ethnopharmacol. 173, 91 (2015), Application(s): ELISA using mouse RAW264.7 cells , Abstract;
Lipin-1 contributes to modified low-density lipoprotein-elicited macrophage pro-inflammatory responses: A.R. Navratil, et al. ; Atherosclerosis 242, 424 (2015), Application(s): ELISA using mouse cell culture supernatant, Abstract;
Molecular characterization and knock-down of salmon louse (Lepeophtheirus salmonis) prostaglandin E synthase: C. Eichner, et al.; Exp. Parasitol. 159, 79 (2015), Application(s): ELISA Kit measuring PGE2 levels in salmon lice, Abstract;
Prostaglandin E2 Production and T Cell Function in Mouse Adenovirus Type 1 Infection following Allogeneic Bone Marrow Transplantation: M.K. McCarthy, et al.; PLoS One 10, e0139235 (2015), Application(s): PGE2 concentration in bronchoalveolar lavage fluid , Abstract; Full Text
Role of gastric acid inhibition, prostaglandins and endogenous-free thiol groups on the gastroprotective effect of a proteolytic fraction from Vasconcellea cundinamarcensis latex: A. Silva, et al.; J. Pharm. Pharmacol. 67, 133 (2015), Application(s): EIA using rat tissue samples, Abstract; Full Text
Supplement of 5-hydroxytryptophan before induction suppresses inflammation and collagen-induced arthritis: T.H. Yang, et al. ; Arthritis. Res. Ther. 17, 364 (2015), Application(s): Measurement of PGE2 in mice serum samples, Abstract; Full Text
The cancer pain related factors affected by celecoxib together with cetuximab in head and neck squamous cell carcinoma: Y. Yang, et al.; Biomed. Pharmacother. 70, 181 (2015), Application(s): ELISA using human culture medium, Abstract;
The Receptor CMRF35-Like Molecule-1 (CLM-1) Enhances the Production of LPS-Induced Pro-Inflammatory Mediators during Microglial Activation: A. Ejarque-Ortiz, et al.; PLoS One 10, e0123928 (2015), Application(s): ELISA using mouse microglial supernatant, Abstract; Full Text
Inhibition of COX-2 and PGE2 in LPS-stimulated RAW264.7 cells by lonimacranthoide VI, a chlorogenic acid ester saponin: F. Guan, et al.; Biomed. Rep. 2, 760 (2014), Application(s): Assay of LPS-stimulated RAW264.7 macrophages, Abstract; Full Text
Possible roles of COX-1 in learning and memory impairment induced by traumatic brain injury in mice: J. Shang, et al.; Braz. J. Med. Biol. Res. 47, 1050 (2014), Application(s): Analysis of PGE2 levels in mouse hippocampus tissue, Abstract; Full Text
Prostaglandin E2 promotes features of replicative senescence in chronically activated human CD8+ T cells: J.P. Chou, et al.; PLoS One 9, e99432 (2014), Application(s): EIA using cell culture supernatants, Abstract; Full Text
Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes: W.Y. Choi, et al.; J. Pharm. Pharmacol. 65, 310 (2013), Application(s): EIA using culture supernatants, Abstract;
Colorectal carcinoma-derived fibroblasts modulate natural killer cell phenotype and antitumor cytotoxicity: T. Li, et al.; Med. Oncol. 30, 663 (2013), Application(s): EIA using culture supernatants, Abstract;
Melanoma-educated CD14+ cells acquire a myeloid-derived suppressor cell phenotype through COX-2-dependent mechanisms: Y. Mao, et al.; Cancer Res. 73, 3877 (2013), Application(s): EIA using culture supernatants, Abstract;
Microenvironment generated during EGFR targeted killing of pancreatic tumor cells by ATC inhibits myeloid-derived suppressor cells through COX2 and PGE2 dependent pathway: A. Thakur, et al.; J. Transl. Med. 11, 35 (2013), Application(s): EIA using culture supernatants from 3D co-cultures, Abstract; Full Text
Prostaglandin E2 alteration in contraceptive consumers: as a risk factor for inflammatory diseases: M.S. Pour, et al.; Arch. Gynecol. Obstet. 287, 1031 (2013), Application(s): EIA using human serum, Abstract;
Transmigration of Neural Stem Cells across the Blood Brain Barrier Induced by Glioma Cells: M. Díaz-Coránguez, et al.; PLoS One 8, e60655 (2013), Application(s): Quantification was done in 4 day CM derived from rat astrocytes and glioma C6 cells using ELISA, Abstract; Full Text
XH-14, a novel danshen methoxybenzo[b]furan derivative, exhibits anti-inflammatory properties in lipopolysaccharide-treated RAW 264.7 cells: G.M. Park, et al.; J. Inflamm. 10, 1 (2013), Application(s): EIA using culture supernatants, Abstract; Full Text
Acacetin protects dopaminergic cells against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced neuroinflammation in vitro and in vivo: H.G. Kim, et al.; Biol. Pharm. Bull. 35, 1287 (2012), Application(s): EIA using culture supernatants, Abstract; Full Text
Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO: T. Li, et al.; Cancer Lett. 318, 154 (2012), Application(s): EIA using culture supernatants, Abstract;
Lycorine inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in RAW264.7 cells through suppressing P38 and STATs activation and increases the survival rate of mice after LPS challenge: J. Kang, et al.; Int. Immunopharmacol. 12, 249 (2012), Application(s): EIA using culture supernatants, Abstract;
Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans: G. Yu, et al.; Am. J. Respir. Crit. Care Med. 186, 752 (2012), Application(s): PGE2 from mice BAL was measured, Abstract;
Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids: W. Stoffel, et al.; EMBO J. 27, 2281 (2008), Application(s): EIA using tissue, Abstract;
Anti-inflammatory effects of isoflavone powder produced from soybean cake: T.H. Kao, et al.; J. Agric. Food Chem. 55, 11068 (2007), Application(s): EIA using peritoneal exudate fluid and peritoneal exudate cell supernatant, Abstract;
Celecoxib inhibits Cdx2 expression and prevents gastric cancer in Helicobacter pylori-infected Mongolian gerbils: S. Futagami, et al.; Digestion 74, 187 (2006), Abstract;
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype: H. Reinold, et al.; J. Clin. Invest. 115, 673 (2005), Application(s): PGE2 from the thoracolumbar segment of the spinal cord was measured, mice, Abstract; Full Text
Effect of a selective cyclooxygenase-2 inhibitor, nimesulide, on the growth of lung tumors and their expression of cyclooxygenase-2 and peroxisome proliferator- activated receptor-gamma: M.S. Shaik, et al.; Clin. Cancer Res. 10, 1521 (2004), Application(s): EIA using mouse tissue, Abstract;
Nonopioid actions of intrathecal dynorphin evoke spinal excitatory amino acid and prostaglandin E2 release mediated by cyclooxygenase-1 and -2: L. Koetzner, et al.; J. Neurosci. 24, 1451 (2004), Application(s): EIA using dialysate, Abstract;
Differential expression of platelet-activating factor acetylhydrolase in macrophages and monocyte-derived dendritic cells: S. Al-Darmaki, et al.; J. Immunol. 170, 167 (2003), Application(s): EIA using human culture supernatants, Abstract;
Inhibition of cyclooxygenase-2 by rofecoxib attenuates the growth and metastatic potential of colorectal carcinoma in mice: M. Yao, et al.; Cancer Res. 63, 586 (2003), Application(s): Concentration of PGE2 in splenic tumor cystosolic fractions were determined using mouse tissue, Abstract;
Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model: D. Claveau, et al.; J. Immunol. 170, 4738 (2003), Application(s): PGE2 production was determined by enzyme immunoassay analysis using rat tissue, Abstract; Full Text
Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients: G. Almer, et al.; Neurology 58, 1277 (2002), Application(s): EIA using cerebral spinal fluid, Abstract;
The effects of periodontal therapy on intracrevicular prostaglandin E2 concentrations and clinical parameters in pregnancy: F. Yalcin, et al.; J. Periodontol. 73, 173 (2002), Application(s): EIA using gingival crevicular fluid, Abstract;
Promoter methylation regulates Helicobacter pylori-stimulated cyclooxygenase-2 expression in gastric epithelial cells: M. Akhtar, et al.; Cancer Res. 61, 2399 (2001), Application(s): EIA using cell culture supernatant, Abstract; Full Text
Inflammatory agonists induce cyclooxygenase type 2 expression by human neutrophils: C.G. Maloney, et al.; J. Immunol. 160, 1402 (1998), Application(s): EIA using human cell culture supernatant, Abstract;
Selective cyclooxygenase-2 inhibition by nimesulide in man: L. Cullen, et al.; J. Pharmacol. Exp. Ther. 287, 578 (1998), Application(s): EIA using plasma, Abstract;
